Asakawa H, Watarai J, Hoshino T
Gan To Kagaku Ryoho. 1984 Jun;11(6):1225-30.
Clinical effectiveness and toxicity of Misonidazole were analyzed and discussed in 22 cases of carcinoma of uterine cervix, 17 cases of esophageal cancer and 11 with other malignancies treated by radiation. By clinical and histologic examination in the controlled trial, it was shown that radiation response of tumor was slightly sensitized in the treated group with this drug, compared with that in the control group. It was confirmed that there was no significant difference between radiation response of tumor in both groups. Peripheral neuropathy was a complication in 10% and toxicodermatitis in 12% even if the total dose administered was below 10 g/m2. From these results, it was strongly suggested that this drug is not suitable in combination with simple fractionated irradiation as a hypoxic cell sensitizer.
分析并讨论了22例子宫颈癌、17例食管癌和11例其他恶性肿瘤患者接受放射治疗时使用米索硝唑的临床疗效和毒性。在对照试验中，通过临床和组织学检查发现，与对照组相比，使用该药物的治疗组肿瘤的放射反应略有增敏。证实两组肿瘤的放射反应无显著差异。即使给药总剂量低于10 g/m2，周围神经病变的发生率为10%，中毒性皮炎的发生率为12%。从这些结果来看，强烈提示该药物作为乏氧细胞增敏剂不适合与单纯分割照射联合使用。
