Lago Bianca Miranda, Bello Stella Dos Santos, Gondim Guilherme Rocha Melo, Makdissi Fabiana Baroni Alves, Bitencourt Almir Galvão Vieira
A.C.Camargo Cancer Center, São Paulo, SP, Brazil.
Radiol Bras. 2023 May-Jun;56(3):145-149. doi: 10.1590/0100-3984.2022.0065-en.
Radiation-induced secondary tumors constitute a rare complication of radiation therapy and typically occur in or near the irradiated area. Women who undergo thoracic radiotherapy before 30 years of age have a significantly greater lifetime risk of developing breast cancer than do those in the general population. It is recommended that a patient who has previously received thoracic radiotherapy with a radiation dose ≥ 10 Gy subsequently undergo annual screening with mammography and magnetic resonance imaging, beginning eight years after the initial treatment or when the patient has reached 25 years of age (whichever comes later). The treatment of secondary breast cancer in this population should be individualized and should be discussed with a multidisciplinary team to avoid toxicity related to the treatment of the primary cancer.
辐射诱发的继发性肿瘤是放射治疗的一种罕见并发症，通常发生在受照射区域或其附近。30岁之前接受胸部放疗的女性患乳腺癌的终生风险显著高于普通人群。建议曾接受胸部放疗且辐射剂量≥10 Gy的患者，在初始治疗八年后或患者年满25岁（以较晚者为准）开始，每年接受乳腺钼靶摄影和磁共振成像筛查。该人群继发性乳腺癌的治疗应个体化，并应与多学科团队讨论，以避免与原发性癌症治疗相关的毒性。
