Gecaite-Stonciene Julija, Rossetti Maria G, Brambilla Paolo, Hughes Brian M, Mickuviene Narseta, Bellani Marcella
Laboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, Palanga, Lithuania.
Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy.
Front Psychiatry. 2023 Jul 26;14:1191007. doi: 10.3389/fpsyt.2023.1191007. eCollection 2023.
The dysregulation of psychophysiological responses to mental stressors is a common issue addressed in individuals with psychiatric conditions, while brain circuit abnormalities are often associated with psychiatric conditions and their manifestations. However, to our knowledge, there is no systematic overview that would comprehensively synthesize the literature on psychophysiological responses during laboratory-induced psychosocial stressor and neural correlates in people with mental disorders. Thus, we aimed to systematically review the existing research on psychophysiological response during laboratory-induced stress and its relationship with neural correlates as measured by magnetic resonance imaging techniques in mental disorders.
The systematic search was performed on PubMed/Medline, EBSCOhost/PsycArticles, Web of Science, and The Cochrane Library databases during November 2021 following the PRISMA guidelines. Risk of bias was evaluated by employing the checklists for cross-sectional and case-control studies from Joanna Briggs Institute (JBI) Reviewers Manual.
Out of 353 de-duplicated publications identified, six studies were included in this review. These studies were identified as representing two research themes: (1) brain anatomy and psychophysiological response to mental stress in individuals with mental disorders, and (2) brain activity and psychophysiological response to mental stress in individuals with mental disorders.
Overall, the evidence from studies exploring the interplay between stress psychophysiology and neural correlates in mental disorders is limited and heterogeneous. Further studies are warranted to better understand the mechanisms of how psychophysiological stress markers interplay with neural correlates in manifestation and progression of psychiatric illnesses.
对精神应激源的心理生理反应失调是精神疾病患者中常见的问题，而脑回路异常通常与精神疾病及其表现相关。然而，据我们所知，尚无系统综述能全面综合关于实验室诱发的心理社会应激源期间的心理生理反应以及精神障碍患者神经相关性的文献。因此，我们旨在系统综述关于实验室诱发应激期间心理生理反应及其与通过磁共振成像技术测量的精神障碍患者神经相关性之间关系的现有研究。
2021年11月，按照PRISMA指南在PubMed/Medline、EBSCOhost/PsycArticles、科学网和考科蓝图书馆数据库进行了系统检索。采用乔安娜·布里格斯研究所（JBI）审稿人手册中横断面研究和病例对照研究的清单评估偏倚风险。
在识别出的353篇去重出版物中，本综述纳入了6项研究。这些研究被确定为代表两个研究主题：（1）精神障碍患者的脑解剖结构与对精神应激的心理生理反应，以及（2）精神障碍患者的脑活动与对精神应激的心理生理反应。
总体而言，探索精神障碍中应激心理生理学与神经相关性之间相互作用的研究证据有限且存在异质性。有必要进行进一步研究，以更好地理解心理生理应激标志物在精神疾病表现和进展过程中如何与神经相关性相互作用的机制。
