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2
A Study of Q-switched Nd:YAG Laser versus Itraconazole in Management of Onychomycosis.调Q开关钕：钇铝石榴石激光与伊曲康唑治疗甲癣的对比研究
J Cutan Aesthet Surg. 2021 Jan-Mar;14(1):93-100. doi: 10.4103/JCAS.JCAS_29_20.
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Dermatol Ther. 2020 Nov;33(6):e12855. doi: 10.1111/dth.12855. Epub 2019 Mar 4.
5
Onychomycosis: Treatment and prevention of recurrence.甲真菌病：治疗和预防复发。
J Am Acad Dermatol. 2019 Apr;80(4):853-867. doi: 10.1016/j.jaad.2018.05.1260. Epub 2018 Jun 28.
6
The efficacy of fractional carbon dioxide (CO) laser combined with terbinafine hydrochloride 1% cream for the treatment of onychomycosis.分次二氧化碳（CO）激光联合1%盐酸特比萘芬乳膏治疗甲真菌病的疗效。
J Cosmet Laser Ther. 2017 Oct;19(6):353-359. doi: 10.1080/14764172.2017.1334925. Epub 2017 May 30.
7
The efficacy of fractional carbon dioxide (CO2) laser combined with luliconazole 1% cream for the treatment of onychomycosis: A randomized, controlled trial.分次二氧化碳（CO₂）激光联合1%卢立康唑乳膏治疗甲真菌病的疗效：一项随机对照试验。
Medicine (Baltimore). 2016 Nov;95(44):e5141. doi: 10.1097/MD.0000000000005141.
8
Fractional carbon-dioxide (CO2) laser-assisted topical therapy for the treatment of onychomycosis.二氧化碳（CO2）激光辅助局部治疗甲真菌病。
J Am Acad Dermatol. 2016 May;74(5):916-23. doi: 10.1016/j.jaad.2015.12.002. Epub 2016 Feb 10.
9
Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream.甲真菌病（趾甲真菌感染）采用分束二氧化碳激光联合局部抗真菌乳膏治疗。
J Am Acad Dermatol. 2014 May;70(5):918-23. doi: 10.1016/j.jaad.2014.01.893. Epub 2014 Mar 18.
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The prevalence of onychomycosis in the global population: a literature study.全球人群中灰指甲的患病率：一项文献研究。
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尿素闭塞后单次分次二氧化碳激光治疗甲癣的初步研究

Single-Session Fractional CO Laser following Urea Occlusion in Management of Onychomycosis: A Pilot Study.

作者信息

Ranjan Eeshaan, Arora Sandeep, Sharma Ajay Shanker, Sharma Neha, Dabas Rajeshwari

机构信息

Department of Dermatology, Military Hospital, Jammu, India.

Department of Dermatology, Base Hospital, Delhi, India.

出版信息

Skin Appendage Disord. 2023 Aug;9(4):268-274. doi: 10.1159/000527252. Epub 2023 Apr 14.

DOI:10.1159/000527252
PMID:37564682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10410086/
Abstract

INTRODUCTION

Onychomycosis is a common nail disorders. Antifungal resistance, interactions, and side effects limit treatment options. Fractional CO (FCO) laser along with topical antifungal is effective in multiple monthly sessions. A modification reducing repeated visits and hence better compliance is preferable. Single-session FCO laser following urea occlusion is reported to be effective. Thus, we conducted a study to determine the efficacy of single-session FCO laser with 1% terbinafine cream with and without "urea cream occlusion" in managing onychomycosis.

METHODS

A prospective, randomized, parallel-group study was conducted at a tertiary centre. Onychomycosis was confirmed by positive fungal mount and culture. Patients were randomized into 2 groups and administered single-session FCO laser. Group A was treated after overnight urea cream occlusion and group B without occlusion. Both groups applied 1% terbinafine cream twice daily for 3 months. Response was assessed by improvement in Onychomycosis Severity Index (OSI) at 6 months.

RESULTS

Group A had 10 patients, 14 nails. Clinical improvement was seen in 12/14 (85.7%) nails. Average reduction in OSI was 10.78. Group B had 10 patients, 11 nails. Clinical improvement was seen in 5/11 (45.5%) nails. Average reduction in OSI was 1.73. "Reduction in OSI" was statistically significant ( < 0.05) only in group A.

CONCLUSION

Single-session FCO laser following overnight urea cream occlusion, followed by 1% terbinafine cream, is effective for management of onychomycosis.

摘要

引言

甲癣是一种常见的指甲疾病。抗真菌耐药性、相互作用和副作用限制了治疗选择。分次二氧化碳（FCO）激光联合外用抗真菌药物在多个月度疗程中有效。减少复诊次数从而提高依从性的改良方法更可取。据报道，尿素封包后单次FCO激光治疗有效。因此，我们开展了一项研究，以确定单次FCO激光联合1%特比萘芬乳膏在有或无“尿素乳膏封包”情况下治疗甲癣的疗效。

方法

在一家三级中心进行了一项前瞻性、随机、平行组研究。通过真菌涂片和培养阳性确诊甲癣。患者被随机分为两组，接受单次FCO激光治疗。A组在夜间使用尿素乳膏封包后进行治疗，B组不进行封包。两组均每天两次涂抹1%特比萘芬乳膏，持续3个月。在6个月时通过甲癣严重程度指数（OSI）的改善情况评估疗效。

结果

A组有10名患者，14枚指甲。14枚指甲中有12枚（85.7%）出现临床改善。OSI平均降低10.78。B组有10名患者，11枚指甲。11枚指甲中有5枚（45.5%）出现临床改善。OSI平均降低1.73。仅A组的“OSI降低”具有统计学意义（<0.05）。

结论

夜间尿素乳膏封包后单次FCO激光治疗，随后使用1%特比萘芬乳膏，对甲癣治疗有效。