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甲癣与皮肤病和血管疾病相关:来自“我们所有人”研究项目的病例对照研究

Onychogryphosis Is Associated with Dermatologic and Vascular Disease: A Case-Control Study of the All of Us Research Program.

作者信息

Choo Zi-Ning, Lipner Shari R

机构信息

Weill Cornell Medical College, New York, NY, USA.

出版信息

Skin Appendage Disord. 2023 Aug;9(4):252-257. doi: 10.1159/000530096. Epub 2023 Apr 20.

DOI:10.1159/000530096
PMID:37564683
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10410083/
Abstract

INTRODUCTION

Onychogryphosis is a nail condition characterized clinically by a thickened, curved, yellow-brown, and opaque nail plate and may result in pain, paronychia, and onychogryphosis.

METHODS

We performed a nested case-control study of 1,114 onychogryphosis patients and 3,423 matched controls to quantify the association between onychogryphosis and self-care limitations, chronic foot injury, dermatologic conditions, and vascular disease.

RESULTS AND CONCLUSION

Onychogryphosis was positively associated with increased age, activity limitations (difficulty running errands alone, bathing, and concentrating), psoriasis, onychomycosis, hallux malleus, hallux valgus, peripheral vascular disease, lower extremity ulcers, venous varices, and type II diabetes mellitus. Therefore, physicians should screen patients presenting with onychogryphosis for these conditions.

摘要

引言

爪状甲是一种指甲病症,临床上表现为甲板增厚、弯曲、呈黄棕色且不透明,可能会导致疼痛、甲沟炎和爪状甲。

方法

我们对1114例爪状甲患者和3423例匹配的对照进行了一项巢式病例对照研究,以量化爪状甲与自我护理受限、慢性足部损伤、皮肤病和血管疾病之间的关联。

结果与结论

爪状甲与年龄增长、活动受限(独自跑腿、洗澡和集中注意力困难)、银屑病、甲癣、锤状趾、拇外翻、外周血管疾病、下肢溃疡、静脉曲张和II型糖尿病呈正相关。因此,医生应对出现爪状甲的患者进行这些病症的筛查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba77/10410083/2beb688dd49b/sad-2023-0009-0004-530096_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba77/10410083/2beb688dd49b/sad-2023-0009-0004-530096_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba77/10410083/2beb688dd49b/sad-2023-0009-0004-530096_F01.jpg

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本文引用的文献

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Optimal diagnosis and management of common nail disorders.常见甲病的最佳诊断与处理。
Ann Med. 2022 Dec;54(1):694-712. doi: 10.1080/07853890.2022.2044511.
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Nail changes in diabetes.糖尿病患者的指甲变化。
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Nail Psoriasis in Older Adults: Intralesional, Systemic, and Biological Therapy.老年人甲银屑病:皮损内、系统和生物治疗。
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Visual Dermatology: A Case of Bilateral Onychogryphosis With Characteristic Dermoscopic Findings.可视化皮肤病学:一例具有特征性皮肤镜表现的双侧甲癣。
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The "All of Us" Research Program.“All of Us”研究计划。
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