Hill Rachel C, Stubblefield Onajia, Vlahovic Tracey C, Lipner Shari R
Weill Cornell Medical College, New York, NY, USA.
University of Louisville School of Medicine, Louisville, KY, USA.
Skin Appendage Disord. 2024 Oct;10(5):421-424. doi: 10.1159/000538969. Epub 2024 May 23.
Onychocryptosis is a common and often painful nail condition, but risk factors have been relatively unexplored. We aimed to analyze associations between onychocryptosis, comorbidities, and income level.
Using the National Institute of Health All of Us Research Program Database, a matched case-control study was performed for patients with onychocryptosis diagnosis and comorbidities and lifestyle factors.
A total of 6,246 cases of onychocryptosis and 24,984 controls were analyzed. Patients with onychocryptosis versus controls had increased risk of onychogryphosis (OR 5.66; 95% CI 4.87, 6.58), onychomycosis (2.63; 2.06, 3.36), hallux valgus (1.68; 1.50, 1.87), type 2 diabetes mellitus (1.49; 1.40, 1.60), obesity (1.38; 1.30, 1.48), and peripheral vascular disease (1.24; 1.14, 1.35) compared to controls. Patients who reported living in low-income households more often had onychocryptosis (reference group annual income >200 k; annual income <10 k USD, OR: 1.76; 95% CI: 1.46, 2.12, < 0.001 vs. annual income 150-200 k USD, OR: 1.26; 95% CI: 0.99, 1.61, = 0.06).
Low income, obesity, PVD, and T2DM were associated with onychocryptosis diagnosis. It is recommended that these at-risk populations be screened for onychocryptosis and counseled on proper nail trimming techniques. Future studies are needed to examine the relationship between household income and onychocryptosis risk.
嵌甲症是一种常见且常伴有疼痛的指甲疾病，但相关危险因素尚未得到充分研究。我们旨在分析嵌甲症、合并症和收入水平之间的关联。
利用美国国立卫生研究院“我们所有人”研究项目数据库，对诊断为嵌甲症及合并症和生活方式因素的患者进行了匹配病例对照研究。
共分析了6246例嵌甲症病例和24984例对照。与对照组相比，嵌甲症患者发生甲癣（比值比[OR] 5.66；95%置信区间[CI] 4.87，6.58）、甲真菌病（2.63；2.06，3.36）、拇外翻（1.68；1.50，1.87）、2型糖尿病（1.49；1.40，1.60）、肥胖（1.38；1.30，1.48）和外周血管疾病（1.24；1.14，1.35）的风险增加。报告生活在低收入家庭的患者更常患嵌甲症（参照组年收入>200k；年收入<10000美元，OR：1.76；95%CI：1.46，2.12，P<0.001；与年收入150 - 200k美元相比，OR：1.26；95%CI：0.99，1.61，P = 0.06）。
低收入、肥胖、外周血管疾病和2型糖尿病与嵌甲症诊断相关。建议对这些高危人群进行嵌甲症筛查，并就正确的指甲修剪技术提供咨询。未来需要进一步研究以探讨家庭收入与嵌甲症风险之间的关系。
