Nose Daisuke, Shiga Yuhei, Takahashi Ryou-U, Yamamoto Yuki, Suematsu Yasunori, Kuwano Takashi, Sugihara Makoto, Kanda Miyuki, Tahara Hidetoshi, Miura Shin-Ichiro
Department of Cardiology, Fukuoka University School of Medicine Fukuoka Japan.
Department of Cellular and Molecular Biology, Hiroshima University Hiroshima Japan.
Circ Rep. 2023 Jul 11;5(8):338-347. doi: 10.1253/circrep.CR-23-0038. eCollection 2023 Aug 10.
The utility of telomere G-tail length to predict coronary artery disease (CAD) remains controversial. CAD results from coronary artery narrowing due to cholesterol and lipid accumulation, augmented by inflammatory cells and other factors. This study explored the significance of telomere G-tail length in suspected CAD patients. In all, 95 patients with suspected CAD or ≥1 cardiac risk factor underwent coronary computed tomography angiography (CCTA). We measured leukocyte telomere length and G-tail length using a hybrid protection method, and diagnosed the presence of CAD using CCTA. Associations between G-tail length and the presence of CAD, the number of stenosed coronary arteries, and brachial-ankle pulse wave velocity (baPWV) were analyzed. No significant difference was observed in G-tail length when comparing groups with or without CAD or statin treatment. However, in the non-statin group, G-tail length was significantly shorter in patients with 3-vessel disease compared with 1-vessel disease. Dividing the group using a baPWV of 1,300 cm/s, telomere G-tail length was significantly shorter in the high-risk (baPWV ≥1,300 cm/s) group. The clinical utility of telomere G-tail length as a CAD risk indicator seems limited. There was a trend for longer telomere G-tail length in the statin-treated group. Moreover, telomere G-tail length was reduced in patients at high-risk of cardiovascular events, aligning with the trend of a shortening in telomere G-tail length with CAD severity.
端粒G尾长度预测冠状动脉疾病（CAD）的效用仍存在争议。CAD是由胆固醇和脂质堆积导致冠状动脉狭窄引起的，炎症细胞和其他因素会加剧这种情况。本研究探讨了端粒G尾长度在疑似CAD患者中的意义。共有95例疑似CAD或有≥1个心脏危险因素的患者接受了冠状动脉计算机断层扫描血管造影（CCTA）。我们使用混合保护法测量白细胞端粒长度和G尾长度，并通过CCTA诊断CAD的存在。分析了G尾长度与CAD存在、冠状动脉狭窄数量以及臂踝脉搏波速度（baPWV）之间的关联。在比较有或无CAD或他汀类药物治疗的组时，未观察到G尾长度有显著差异。然而，在非他汀类药物组中，三支血管病变患者的G尾长度明显短于单支血管病变患者。以1300 cm/s的baPWV对该组进行划分，高危（baPWV≥1300 cm/s）组的端粒G尾长度明显较短。端粒G尾长度作为CAD风险指标的临床效用似乎有限。他汀类药物治疗组中端粒G尾长度有延长的趋势。此外，心血管事件高危患者的端粒G尾长度缩短，这与端粒G尾长度随CAD严重程度缩短的趋势一致。
