Wai Kyi Mar, Kaori Sawada, Itoh Ken, Shinya Okuyama, Uchikawa Yuka, Hayashi Sakura, Shiraki Akiko, Murashita Koichi, Nakaji Shigeyuki, Ihara Kazushige
Department of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, Japan.
Department of Human Ecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
J Pers Med. 2021 Dec 2;11(12):1278. doi: 10.3390/jpm11121278.
Telomere (TL) is a biomarker of biological aging, and its shortening is associated with major risk factors for cardiovascular diseases (CVD). This study aimed to identify whether TL is associated with arterial stiffness as reflected by brachial-ankle pulse wave velocity (baPWV). This population-based cross-sectional study involved 1065 individuals in the Iwaki area, Japan. Total TL length and TL G-tail length were measured by hybridization protection assay. The baPWV was measured on the right and left sides using a non-invasive vascular screening device. The associations between TL and baPWV were assessed by multivariate linear regression. Compared with the shortest total TL tertile, the longest total TL group showed a significant decrease in baPWV (lowest vs. highest tertile: adjusted beta: -41.24, 95% confidence interval (CI): -76.81, -5.68). The mean baPWV decreased with a longer TL (TL G-tail length: trend < 0.001, total TL: trend < 0.001). TL G-tail and total TL lengths were inversely associated with baPWV, implicating TL shortening in the development of CVD. This study provides evidence of the factors influencing CVD risks at a very early stage when individuals can still take necessary precautions before CVD gives rise to a symptomatic health outcome.
端粒（TL）是生物衰老的一个生物标志物，其缩短与心血管疾病（CVD）的主要危险因素相关。本研究旨在确定TL是否与肱踝脉搏波速度（baPWV）所反映的动脉僵硬度相关。这项基于人群的横断面研究涉及日本磐城地区的1065名个体。通过杂交保护测定法测量总TL长度和TL G尾长度。使用非侵入性血管筛查设备测量左右两侧的baPWV。通过多变量线性回归评估TL与baPWV之间的关联。与总TL最短三分位数组相比，总TL最长组的baPWV显著降低（最低三分位数与最高三分位数：调整后的β：-41.24，95%置信区间（CI）：-76.81，-5.68）。baPWV平均值随TL延长而降低（TL G尾长度：趋势<0.001，总TL：趋势<0.001）。TL G尾和总TL长度与baPWV呈负相关，提示TL缩短与CVD的发生有关。本研究提供了证据，表明在个体仍可在CVD导致有症状的健康结果之前采取必要预防措施的非常早期阶段，存在影响CVD风险的因素。
