Nakai K, Itakura T, Naka Y, Nakakita K, Kamei I, Imai H, Yokote H, Komai N
Brain Res. 1986 Aug 27;381(1):148-52. doi: 10.1016/0006-8993(86)90703-1.
The first morphological evidence of the existence of adrenergic receptors (alpha 1, alpha 2 and beta) within the vascular walls of the central nervous system were presented using the in vitro receptor autoradiographic technique. In the rat pial arteries all three types of adrenergic receptors were demonstrated, whereas the human pial arteries failed to show significant autoradiographic grains of alpha 1 type of adrenergic receptors indicating a considerable inter-species difference in the distribution of adrenergic receptors. alpha 2 and beta receptors in human pial arteries were found not only in the arterial smooth muscle layers but also in the endothelial layers. This suggests a possibility that circulating sympathomimetic agents play some role in controlling the tone or permeability of vascular walls within the central nervous system. A distinct distribution of alpha 1 receptors in cortical layer IV where the vascular plexus was richest may suggest a relation of alpha 1 receptors and blood flow of brain parenchyma.
利用体外受体放射自显影技术，首次提供了中枢神经系统血管壁内存在肾上腺素能受体（α1、α2和β）的形态学证据。在大鼠软脑膜动脉中证实了所有三种类型的肾上腺素能受体，而人类软脑膜动脉未显示出α1型肾上腺素能受体明显的放射自显影颗粒，这表明肾上腺素能受体分布存在相当大的种间差异。人类软脑膜动脉中的α2和β受体不仅存在于动脉平滑肌层，也存在于内皮细胞层。这提示循环拟交感神经药物在控制中枢神经系统血管壁的张力或通透性方面可能发挥一定作用。在血管丛最丰富的皮质IV层中α1受体的独特分布可能表明α1受体与脑实质血流之间存在关联。
