Lechuga Guilherme C, Morel Carlos M, De-Simone Salvatore Giovanni
Center for Technological Development in Health (CDTS)/ National Institute of Science and Technology for Innovation in Neglected Population Diseases (INCT-IDPN), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
Laboratory of Epidemiology and Molecular Systematics (LESM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
Front Physiol. 2023 Jul 24;14:1203472. doi: 10.3389/fphys.2023.1203472. eCollection 2023.
Long COVID-19 is a condition characterized by persistent symptoms lasting beyond the acute phase of COVID-19. Long COVID-19 produces diverse symptomatology and can impact organs and systems, including the hematological system. Several studies have reported, in COVID-19 patients, hematological abnormalities. Most of these alterations are associated with a higher risk of severe disease and poor outcomes. This literature review identified studies reporting hematological parameters in individuals with Long COVID-19. Findings suggest that Long COVID-19 is associated with a range of sustained hematological alterations, including alterations in red blood cells, anemia, lymphopenia, and elevated levels of inflammatory markers such as ferritin, D-dimer, and IL-6. These alterations may contribute to a better understanding of the pathophysiology of Long COVID-19 and its associated symptoms. However, further research is needed to elucidate the underlying mechanisms and potential treatments for these hematological changes in individuals with Long COVID-19.
新冠后综合征是一种以持续症状为特征的病症,这些症状在新冠急性期之后仍持续存在。新冠后综合征会产生多种症状,并可能影响包括血液系统在内的多个器官和系统。多项研究报告了新冠患者存在血液学异常。这些改变大多与严重疾病风险增加和不良预后相关。这篇文献综述确定了报告新冠后综合征患者血液学参数的研究。研究结果表明,新冠后综合征与一系列持续的血液学改变有关,包括红细胞改变、贫血、淋巴细胞减少以及铁蛋白、D-二聚体和白细胞介素-6等炎症标志物水平升高。这些改变可能有助于更好地理解新冠后综合征的病理生理学及其相关症状。然而,需要进一步研究以阐明新冠后综合征患者这些血液学变化的潜在机制和可能的治疗方法。