Department of Biomedical Engineering, Chemical Engineering and Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven, 5600MB, The Netherlands.
School of Biotechnology and Biomolecular Science, University of New South Wales, Sydney, NSW, 2052, Australia.
Adv Biol (Weinh). 2023 Dec;7(12):e2300149. doi: 10.1002/adbi.202300149. Epub 2023 Aug 10.
The fast-growing pace of regenerative medicine research has allowed the development of a range of novel approaches to tissue engineering applications. Until recently, the main points of interest in the majority of studies have been to combine different materials to control cellular behavior and use different techniques to optimize tissue formation, from 3-D bioprinting to in situ regeneration. However, with the increase of the understanding of the fundamentals of cellular organization, tissue development, and regeneration, has also come the realization that for the next step in tissue engineering, a higher level of spatiotemporal control on cell-matrix interactions is required. It is proposed that the combination of artificial cell research with tissue engineering could provide a route toward control over complex tissue development. By equipping artificial cells with the underlying mechanisms of cellular functions, such as communication mechanisms, migration behavior, or the coherent behavior of cells depending on the surrounding matrix properties, they can be applied in instructing native cells into desired differentiation behavior at a resolution not to be attained with traditional matrix materials.
再生医学研究的快速发展使得一系列新型组织工程应用方法得以开发。直到最近，大多数研究的主要关注点一直是结合不同的材料来控制细胞行为，并使用不同的技术来优化组织形成，从三维生物打印到原位再生。然而，随着对细胞组织、组织发育和再生基本原理的理解的增加，人们也意识到，为了实现组织工程的下一步发展，需要对细胞-基质相互作用进行更高水平的时空控制。有人提出，将人工细胞研究与组织工程相结合，可以为控制复杂的组织发育提供一条途径。通过为人工细胞配备细胞功能的基本机制，如通信机制、迁移行为，或根据周围基质特性的细胞协调行为，它们可以应用于指导天然细胞按照期望的分化行为进行分化，而这是传统基质材料无法达到的分辨率。
