Faculty of Engineering Science, University of Bayreuth, Universitätsstr. 30, 95440, Bayreuth, Germany.
Adv Healthc Mater. 2018 Sep;7(17):e1800412. doi: 10.1002/adhm.201800412. Epub 2018 Jul 5.
The mission of regenerative medicine is the development of methods to regrow, repair, or replace damaged or diseased cells, organs, or tissues. 3D bioprinting techniques are one of the most promising approaches for engineering the design of artificial tissues. Current 3D bioprinting technologies possess, however, several intrinsic limitations. 4D biofabrication, a recently developed technology with the embedded ability of shape transformation upon response to intrinsic and/or external stimuli, may solve challenges of 3D bioprinting as well as more accurately mimic the dynamics of the native tissues. This article covers recent advances in 4D biofabrication. It gives a detailed picture of used materials and technologies, provides critical comparisons of methods, discusses possibilities and limitations of different 4D biofabrication technologies, and gives examples of applications.
再生医学的任务是开发方法来再生、修复或替换受损或患病的细胞、器官或组织。3D 生物打印技术是工程设计人工组织的最有前途的方法之一。然而，目前的 3D 生物打印技术存在一些内在的局限性。4D 生物制造，一种最近开发的技术，具有在响应内在和/或外部刺激时进行形状转换的嵌入式能力，可能会解决 3D 生物打印的挑战，并更准确地模拟天然组织的动态。本文介绍了 4D 生物制造的最新进展。它详细介绍了使用的材料和技术，对方法进行了批判性比较，讨论了不同 4D 生物制造技术的可能性和局限性，并举例说明了应用。
