Department of Obstetrics and Gynecology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China.
Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Medicine (Baltimore). 2023 Aug 11;102(32):e34734. doi: 10.1097/MD.0000000000034734.
Malignant transformation of mature cystic teratoma is very rare, of which squamous cell carcinoma (SCC) is the most common type. Prognosis of SCC arising in mature cystic teratoma of the ovary is very poor. Our experience may provide new ideas for the treatment of this disease.
The patient was a 56-year-old woman and was admitted for a lower abdominal pain. She underwent a laparoscopic surgery with 4 cycles of chemotherapy and had achieved a complete response; 10 months after the completion of initial treatment, her cancer relapsed. She underwent a cytoreductive surgery with concurrent chemoradiotherapy and has achieved a complete response again.
This patient was initially diagnosed with ovarian cancer (stage IIIB) arising from malignant transformation of mature teratoma; 10 months after the completion of initial treatment, she was diagnosed with recurrent ovarian cancer.
This patient was initially treated with laparoscopic bilateral salpingo-oophorectomy. After histopathological confirmation that she had ovarian cancer, she underwent laparoscopic total hysterectomy and omentectomy with 4 cycles of chemotherapy. After her ovarian cancer recurred, she underwent open cytoreductive surgery and concurrent chemoradiotherapy.
The patient achieved complete response after both initial and relapsed treatment.
Optimal cytoreduction and concurrent chemoradiotherapy may be an option to improve the prognosis of patients with recurrent SCC arising in ovary mature cystic teratoma.
成熟囊性畸胎瘤恶变非常罕见，其中以鳞状细胞癌（SCC）最为常见。卵巢成熟囊性畸胎瘤恶变 SCC 的预后非常差。我们的经验可能为这种疾病的治疗提供新的思路。
患者为 56 岁女性，因下腹疼痛就诊。她接受了腹腔镜手术和 4 个周期的化疗，达到完全缓解；初始治疗完成后 10 个月，癌症复发。她接受了肿瘤细胞减灭术联合化疗和放疗，再次达到完全缓解。
该患者最初被诊断为卵巢癌（IIIb 期），来源于成熟畸胎瘤的恶性转化；初始治疗完成后 10 个月，诊断为复发性卵巢癌。
该患者最初接受腹腔镜双侧输卵管卵巢切除术。组织病理学证实为卵巢癌后，她接受了腹腔镜全子宫切除术和大网膜切除术，并进行了 4 个周期的化疗。卵巢癌复发后，她接受了开腹肿瘤细胞减灭术和同步放化疗。
该患者在初始和复发治疗后均达到完全缓解。
最佳的肿瘤细胞减灭术和同步放化疗可能是改善复发性卵巢成熟囊性畸胎瘤 SCC 患者预后的选择。
