采用同步放化疗姑息治疗成熟性囊性畸胎瘤IV期恶性转化：一例报告
Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy: A case report.
作者信息
Kondo Saori, Suzuki Takashi, Yoshiike Kanato, Yamanaka Sakura, Sonehara Kenta, Nabeshima Hiroshi, Oguchi Osamu
机构信息
Department of Obstetrics and Gynecology, Saku Central Hospital Advanced Care Center, Saku City 385-0051, Nagano, Japan.
出版信息
World J Clin Cases. 2025 Jan 6;13(1):99938. doi: 10.12998/wjcc.v13.i1.99938.
BACKGROUND
Malignant transformation (MT) of mature cystic teratoma (MCT) has a poor prognosis, especially in advanced cases. Concurrent chemoradiotherapy (CCRT) has an inhibitory effect on MT.
CASE SUMMARY
Herein, we present a case in which CCRT had a reduction effect preoperatively. A 73-year-old woman with pyelonephritis was referred to our hospital. Computed tomography revealed right hydronephrosis and a 6-cm pelvic mass. Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) revealed squamous cell carcinoma. The patient was diagnosed with MT of MCT. Due to her poor general condition and renal malfunction, we selected CCRT, expecting fewer adverse effects. After CCRT, her performance status improved, and the tumor size was reduced; surgery was performed. Five months postoperatively, the patient developed dissemination and lymph node metastases. Palliative chemotherapy was ineffective. She died 18 months after treatment initiation.
CONCLUSION
EUS-FNB was useful in the diagnosis of MT of MCT; CCRT suppressed the disease and improved quality of life.
背景
成熟性囊性畸胎瘤（MCT）的恶性转化（MT）预后较差，尤其是在晚期病例中。同步放化疗（CCRT）对MT有抑制作用。
病例摘要
在此，我们报告一例CCRT术前具有缩小肿瘤作用的病例。一名73岁患有肾盂肾炎的女性被转诊至我院。计算机断层扫描显示右肾积水和一个6厘米的盆腔肿块。内镜超声引导下细针穿刺活检（EUS-FNB）显示为鳞状细胞癌。该患者被诊断为MCT的MT。由于她的一般状况较差且存在肾功能不全，我们选择了CCRT，期望不良反应较少。CCRT后，她的体能状态得到改善，肿瘤大小缩小；随后进行了手术。术后五个月，患者出现播散和淋巴结转移。姑息化疗无效。她在开始治疗18个月后死亡。
结论
EUS-FNB对MCT的MT诊断有用；CCRT抑制了疾病进展并改善了生活质量。
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