Heilongjiang University of Traditional Chinese Medicine, Harbin, China.
Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Medicine (Baltimore). 2023 Aug 11;102(32):e34540. doi: 10.1097/MD.0000000000034540.
Hyperuricemia nephropathy, also known as gouty nephropathy, refers to renal damage induced by hyperuricemia caused by excessive production of serum uric acid or low excretion of uric acid. the persistence of symptoms will lead to changes in renal tubular phenotype and accelerate the progress of renal fibrosis. The existence and progressive aggravation of symptoms will bring a heavy burden to patients, their families and society, affect their quality of life and reduce their well-being. With the increase of reports on hyperuricemia nephropathy, the importance of related signal pathways in the pathogenesis of hyperuricemia nephropathy is becoming more and more obvious, but most studies are limited to the upper and lower mediating relationship between 1 or 2 signal pathways. The research on the comprehensiveness of signal pathways and the breadth of crosstalk between signal pathways is limited. By synthesizing the research results of signal pathways related to hyperuricemia nephropathy in recent years, this paper will explore the specific mechanism of hyperuricemia nephropathy, and provide new ideas and methods for the treatment of hyperuricemia nephropathy based on a variety of signal pathway crosstalk and personal prospects.
高尿酸血症肾病，又称痛风性肾病，是指由于血清尿酸生成过多或尿酸排泄减少所致的血尿酸升高引起的肾脏损害。症状的持续存在会导致肾小管表型的改变，并加速肾纤维化的进展。症状的存在和逐渐加重会给患者及其家庭和社会带来沉重的负担，影响他们的生活质量，降低他们的幸福感。随着高尿酸血症肾病相关报道的增加，相关信号通路在高尿酸血症肾病发病机制中的重要性日益明显，但大多数研究仅限于 1 或 2 条信号通路的上下介导关系。对信号通路的全面性和信号通路之间的广泛串扰的研究是有限的。通过综合近年来与高尿酸血症肾病相关的信号通路研究结果，本文将探讨高尿酸血症肾病的具体发病机制，并基于多种信号通路串扰和个人前景，为高尿酸血症肾病的治疗提供新的思路和方法。
