Tahiliani A G, McNeill J H
Can J Physiol Pharmacol. 1986 Jun;64(6):669-72. doi: 10.1139/y86-110.
Streptozocin-diabetic rats were treated with a combination of triiodothyronine and carnitine for 6 weeks. These compounds were used as they are known to correct the diabetes-induced depression of cardiac myosin ATPase and sarcoplasmic reticular (SR) calcium uptake, respectively. Myocardial performance, which was assessed using the working heart preparation, revealed a depression of function in untreated diabetics when compared with controls at most left atrial filling pressures. Hearts from diabetic rats treated with the combination exhibited depression at only the higher filling pressures as compared with untreated or treated controls. The results suggest that functional alterations occurring as a result of diabetes cannot be accounted for by the depression of cardiac myosin ATPase and SR calcium uptake alone.
用链脲佐菌素诱导糖尿病大鼠，并用三碘甲状腺原氨酸和肉碱联合治疗6周。使用这两种化合物是因为已知它们分别可纠正糖尿病引起的心肌肌球蛋白ATP酶活性降低和肌浆网（SR）钙摄取减少。使用工作心脏标本评估心肌功能，结果显示，在大多数左心房充盈压下，未治疗的糖尿病大鼠与对照组相比，心脏功能降低。与未治疗或经治疗的对照组相比，联合治疗的糖尿病大鼠心脏仅在较高充盈压下表现出功能降低。结果表明，糖尿病导致的功能改变不能仅由心肌肌球蛋白ATP酶活性降低和SR钙摄取减少来解释。
