Rodrigues B, Xiang H, McNeill J H
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
Diabetes. 1988 Oct;37(10):1358-64. doi: 10.2337/diab.37.10.1358.
The beneficial effects of L-carnitine administration were studied in vivo in isolated perfused working hearts from control and diabetic rats. Control and streptozocin-induced diabetic (STZ-D) rats were treated daily for 6 wk with high-dose L-carnitine (3 g.kg-1.day-1 i.p.). STZ-D results in loss of body weight and hypoinsulinemia. These effects were not altered by L-carnitine treatment. Myocardial free-carnitine levels were decreased in the untreated diabetic rats. L-Carnitine treatment of the diabetic rats increased myocardial free-carnitine levels, which were comparable with those of control rats. Six weeks after STZ administration, hearts from untreated diabetic animals exhibited depressed left ventricular developed pressure, cardiac contractility, and ventricular relaxation rates compared with control animals. However, this depression was not seen in the L-carnitine-treated diabetic animals. L-Carnitine treatment of diabetic rats significantly reduced plasma glucose and lipid levels but had no effect on control rats. Furthermore, thyroid hormone levels were higher in the L-carnitine-treated diabetic rats than in the untreated diabetic group. The data suggest that high-dose L-carnitine treatment may reduce the severity of diabetes and result in improved cardiac performance.
在来自对照大鼠和糖尿病大鼠的离体灌注工作心脏中，对左旋肉碱给药的有益效果进行了体内研究。对照大鼠和链脲佐菌素诱导的糖尿病（STZ-D）大鼠每天腹腔注射高剂量左旋肉碱（3 g·kg⁻¹·天⁻¹），持续6周。STZ-D会导致体重减轻和低胰岛素血症。这些影响并未因左旋肉碱治疗而改变。未治疗的糖尿病大鼠心肌游离肉碱水平降低。对糖尿病大鼠进行左旋肉碱治疗可提高心肌游离肉碱水平，使其与对照大鼠相当。给予STZ六周后，与对照动物相比，未治疗的糖尿病动物的心脏表现出左心室舒张末压、心脏收缩力和心室舒张速率降低。然而，在接受左旋肉碱治疗的糖尿病动物中未观察到这种降低。对糖尿病大鼠进行左旋肉碱治疗可显著降低血糖和血脂水平，但对对照大鼠无影响。此外，接受左旋肉碱治疗的糖尿病大鼠的甲状腺激素水平高于未治疗的糖尿病组。数据表明，高剂量左旋肉碱治疗可能会减轻糖尿病的严重程度并改善心脏功能。
Zotero 插件