Department of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala 133207, India.
Punjab Biotechnology Incubator (PBTI), Phase VIII, Mohali 160071, India.
Molecules. 2022 Nov 7;27(21):7653. doi: 10.3390/molecules27217653.
Despite the immense therapeutic advances in the field of health sciences, cancer is still to be found among the global leading causes of morbidity and mortality. Ethnomedicinally, natural bioactive compounds isolated from various plant sources have been used for the treatment of several cancer types and have gained notable attention. Ferulic acid, a natural compound derived from various seeds, nuts, leaves, and fruits, exhibits a variety of pharmacological effects in cancer, including its proapoptotic, cell-cycle-arresting, anti-metastatic, and anti-inflammatory activities. This review study presents a thorough overview of the molecular targets and cellular signaling pathways modulated by ferulic acid in diverse malignancies, showing high potential for this phenolic acid to be developed as a candidate agent for novel anticancer therapeutics. In addition, current investigations to develop promising synergistic formulations are also discussed.
尽管在健康科学领域取得了巨大的治疗进展，但癌症仍然是全球发病率和死亡率的主要原因之一。在民族医学中，从各种植物来源中分离出的天然生物活性化合物已被用于治疗多种癌症类型，并引起了人们的关注。阿魏酸是一种从各种种子、坚果、叶子和水果中提取的天然化合物，在癌症中表现出多种药理作用，包括促凋亡、细胞周期停滞、抗转移和抗炎作用。本综述研究全面概述了阿魏酸在多种恶性肿瘤中调节的分子靶点和细胞信号通路，表明这种酚酸具有很大的潜力，可以开发为新型抗癌治疗的候选药物。此外，还讨论了目前开发有前途的协同配方的研究。
