第二代QuantiFERON-TB Gold-Plus抗原管在西班牙儿童结核病诊断及治疗结束时的价值
The Value of the Second QuantiFERON-TB Gold-Plus Antigen Tube at Diagnosis and at Treatment Completion in Spanish Children With Tuberculosis.
作者信息
Soler-Garcia Aleix, Gamell Anna, Monsonís Manuel, Korta-Murua José Javier, Espiau María, Rincón-López Elena, Rodríguez-Molino Paula, Pérez-Porcuna Tomàs, Bustillo-Alonso Matilde, Santiago Begoña, Tebruegge Marc, Noguera-Julian Antoni
机构信息
From the Malalties Infeccioses i Resposta Inflamatòria Sistèmica en Pediatria, Servei de Malalties Infeccioses i Patologia Importada, Institut de Recerca Pediàtrica Sant Joan de Déu, Barcelona, Spain.
Servei de Microbiologia, Hospital Sant Joan de Déu, Barcelona, Spain.
出版信息
Pediatr Infect Dis J. 2023 Nov 1;42(11):1017-1020. doi: 10.1097/INF.0000000000004058. Epub 2023 Aug 1.
We studied 295 children (tuberculosis disease, n = 159; latent tuberculosis infection, n = 136) with positive QuantiFERON-TB Gold-Plus assay results. No significant differences between first and second antigen tube interferon-gamma responses were detected, irrespective of patient and disease characteristics at diagnosis. Of patients with a repeat assay after treatment completion (n = 65), only 16.9% converted to negative results.
我们研究了295名QuantiFERON-TB Gold-Plus检测结果呈阳性的儿童（结核病患者，n = 159；潜伏性结核感染患者，n = 136）。无论诊断时的患者和疾病特征如何，首次和第二次抗原管干扰素-γ反应之间均未检测到显著差异。在治疗完成后进行重复检测的患者中（n = 65），只有16.9%的检测结果转为阴性。
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