Du Yuxia, Yan Rui, Wu Xiaoyue, Zhang Xiaobao, Chen Can, Jiang Daixi, Yang Mengya, Cao Kexin, Chen Mengsha, You Yue, Zhou Wenkai, Chen Dingmo, Xu Gang, Yang Shigui
Department of Emergency Medicine, Second Affiliated Hospital, Department of Public Health, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.
Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, China.
Int J Infect Dis. 2023 Oct;135:70-76. doi: 10.1016/j.ijid.2023.08.008. Epub 2023 Aug 10.
Understanding the global patterns of respiratory syncytial virus (RSV) is crucial for developing effective prevention and control strategies.
Data on RSV-related burden were extracted from the Global Burden of Disease 2019. Joinpoint regression models were used to assess the global temporal trends of RSV and further stratified analyses were conducted according to the Socio-demographic Index (SDI), which is a composite measure of income, education, and total fertility. Age-period-cohort model was used to evaluate age, period, and cohort effects.
In 2019, the global age-standardized rate of mortality (ASMR) and disability-adjusted life years (ASR-DALYs) of RSV were 4.79/100,000 (95% uncertainty interval [95% UI]: 1.82/100,000-9.32/100,000) and 218.34/100,000 (95% UI: 92.06/100,000-376.80/100,000), respectively. The burden of RSV was higher in men than women. The highest ASMR (10.26/100,000, 3.80/100,000-20.16/100,000) and ASR-DALYs (478.71/100,000, 202.40/100,000-840.85/100,000) were reported in low-SDI region. Although mortality and DALYs rates in all age groups declined globally, the pace of decline was not uniform across age groups. Mortality rate in the elderly over 70 years surpassed that in children under 5 years in 2019.
This study highlights the need for targeted interventions to reduce the burden of RSV, particularly in low-SDI region, and among the elderly over 70 years.
了解全球呼吸道合胞病毒（RSV）流行模式对于制定有效的预防和控制策略至关重要。
从《2019年全球疾病负担》中提取RSV相关负担的数据。采用Joinpoint回归模型评估RSV的全球时间趋势，并根据社会人口指数（SDI）进行进一步分层分析，SDI是收入、教育和总和生育率的综合指标。使用年龄-时期-队列模型评估年龄、时期和队列效应。
2019年，RSV的全球年龄标准化死亡率（ASMR）和伤残调整生命年（ASR-DALYs）分别为4.79/10万（95%不确定区间[95% UI]：1.82/10万-9.32/10万）和218.34/10万（95% UI：92.06/10万-376.80/10万）。RSV的负担男性高于女性。低SDI地区报告的ASMR最高（10.26/10万，3.80/10万-20.16/10万）和ASR-DALYs最高（478.71/10万，202.40/10万-840.85/10万）。尽管全球所有年龄组的死亡率和DALYs率均有所下降，但各年龄组的下降速度并不一致。2019年，70岁以上老年人的死亡率超过了5岁以下儿童。
本研究强调需要采取有针对性的干预措施来减轻RSV的负担，特别是在低SDI地区以及70岁以上的老年人中。
