Aihara Masakazu, Hayashi Takanori, Koizumi Chie, Sakurai Yoshitaka, Sawada Mika, Kubota Tetsuya, Kadowaki Takashi, Yamauchi Toshimasa, Kubota Naoto
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Department of Clinical Nutrition, Health and Nutrition (NIBIOHN), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Tokyo, Japan.
Diabetes Ther. 2023 Oct;14(10):1711-1721. doi: 10.1007/s13300-023-01452-y. Epub 2023 Aug 11.
Hemoglobin A1c (HbA1c), representing the average blood glucose over 1-2 months, is the most commonly used glycemic marker in people with diabetes. Glycated albumin (GA) reflects the average blood glucose over the most recent 1-2 weeks. We considered whether the faster response of GA compared with HbA1c could make people with diabetes realize their glycemic control intuitively and effectively.
We randomized 61 people with diabetes into the control and intervention groups. Blood samples were collected from both every fortnight over an 8-week period (five times; visit 1-5). Only the intervention group was notified of the GA levels on the same day. At the beginning and end of the study, International Physical Activity Questionnaire and Eating Behavior Questionnaire assessments, and body composition measurements were conducted.
The body weight change was significantly lower in the intervention group at visit 2 and visit 5. The percent body fat change was lower, while the percent skeletal muscle mass change at visit 5 was higher in the intervention group. Increasing GA trend was observed in the control group, but not in the intervention group. The fasting plasma glucose and HbA1c changes at visit 5 were similar in the two groups. Physical activity level change tended to be higher in the intervention group. The YN Eating Behavior Questionnaire score changes were similar in the two groups.
Bi-weekly GA measurement over an 8-week period in people with type 2 diabetes induced behavioral changes. Development of this method is expected to improve diabetes management.
UMIN000037795.
糖化血红蛋白（HbA1c）代表1 - 2个月内的平均血糖水平，是糖尿病患者最常用的血糖指标。糖化白蛋白（GA）反映最近1 - 2周的平均血糖水平。我们探讨了与HbA1c相比，GA更快的反应是否能使糖尿病患者直观且有效地实现血糖控制。
我们将61例糖尿病患者随机分为对照组和干预组。在8周内每两周采集一次两组的血样（共5次；第1 - 5次访视）。仅向干预组告知当日的GA水平。在研究开始和结束时，进行国际体力活动问卷和饮食行为问卷评估以及身体成分测量。
在第2次和第5次访视时，干预组的体重变化显著更低。干预组的体脂百分比变化更低，而在第5次访视时骨骼肌质量百分比变化更高。对照组观察到GA呈上升趋势，而干预组未观察到。两组在第5次访视时的空腹血糖和HbA1c变化相似。干预组的体力活动水平变化趋势更高。两组的YN饮食行为问卷评分变化相似。
对2型糖尿病患者在8周内每两周测量一次GA可引起行为改变。预计该方法的开发将改善糖尿病管理。
UMIN000037795
