Verykokou Styliani, Ioannidis Charalabos, Angelopoulos Christos
Laboratory of Photogrammetry, School of Rural, Surveying and Geoinformatics Engineering, National Technical University of Athens, 15780 Athens, Greece.
Department of Oral Diagnosis and Radiology, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece.
J Clin Med. 2023 Jul 30;12(15):5023. doi: 10.3390/jcm12155023.
The purpose of this article is to define and implement a methodology for the 3D design of customized patient-specific scaffolds (bone grafts) for the regeneration of periodontal tissues. The prerequisite of the proposed workflow is the three-dimensional (3D) structure of the periodontal defect, i.e., the 3D model of the hard tissues (alveolar bone and teeth) around the periodontal damage, which is proposed to be generated via a segmentation and 3D editing methodology using cone beam computed tomography (CBCT) data. Two types of methodologies for 3D periodontal scaffold (graft) design are described: (i) The methodology of designing periodontal defect customized block grafts and (ii) the methodology of designing extraction socket preservation customized grafts. The application of the proposed methodology for the generation of a 3D model of the hard tissues around periodontal defects of a patient using a CBCT scan and the 3D design of the two aforementioned types of scaffolds for personalized periodontal regenerative treatment shows promising results. The outputs of this work will be used as the basis for the 3D printing of bioabsorbable scaffolds of personalized treatment against periodontitis, which will simultaneously be used as sustained-release drug carriers.
本文的目的是定义并实施一种方法，用于设计定制的患者特异性支架（骨移植物），以实现牙周组织再生的三维（3D）设计。所提出工作流程的前提是牙周缺损的三维（3D）结构，即牙周损伤周围硬组织（牙槽骨和牙齿）的3D模型，建议通过使用锥形束计算机断层扫描（CBCT）数据的分割和3D编辑方法来生成该模型。本文描述了两种用于3D牙周支架（移植物）设计的方法：（i）设计牙周缺损定制块状移植物的方法和（ii）设计拔牙窝保存定制移植物的方法。使用CBCT扫描为患者牙周缺损周围的硬组织生成3D模型，并对上述两种类型的支架进行3D设计以进行个性化牙周再生治疗，所提出方法的应用显示出了有前景的结果。这项工作的成果将作为针对牙周炎的个性化治疗用生物可吸收支架3D打印的基础，该支架同时还将用作缓释药物载体。
