Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan.
Department of Periodontology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea.
Orthod Craniofac Res. 2019 May;22 Suppl 1(Suppl 1):69-75. doi: 10.1111/ocr.12275.
The reconstruction of alveolar bone defects associated with teeth and dental implants remains a clinical challenge in the treatment of patients affected by disease or injury of the alveolus. The aim of this review was to provide an overview on advances made in the use of personalized scaffolding technologies coupled with biologics, cells and gene therapies that offer future clinical applications for the treatment of patients requiring periodontal and alveolar bone regeneration. Over the past decade, advancements in three-dimensional (3D) imaging acquisition technologies such as cone-beam computed tomography (CBCT) and precise scaffold fabrication methods such as 3D bioprinting have resulted in personalized scaffolding constructs based on individual patient-specific anatomical data. Furthermore, 'fiber-guiding' scaffold designs utilize topographical cues to guide ligamentous fibers to form in orientation towards the root surface to improve tooth support. Therefore, a topic-focused literature search was conducted looking into fiber-guiding and image-based scaffolds and their associated clinical applications.
与牙齿和牙种植体相关的牙槽骨缺损的重建仍然是治疗受牙槽疾病或损伤影响的患者的临床挑战。本综述的目的是概述个性化支架技术与生物制剂、细胞和基因治疗相结合的最新进展，为需要牙周和牙槽骨再生的患者的治疗提供未来的临床应用。在过去的十年中，三维（3D）成像采集技术（如锥形束 CT（CBCT））和精确支架制造方法（如 3D 生物打印）的进步，基于个体患者特定的解剖学数据，产生了个性化支架结构。此外，“纤维引导”支架设计利用地形线索引导韧带纤维朝着根表面的方向形成，以改善牙齿支撑。因此，进行了一个主题聚焦的文献检索，研究了纤维引导和基于图像的支架及其相关的临床应用。
