Swamynathan Rithvik, Varadarajan Vinithra, Nguyen Hieu, Wu Colin O, Liu Kiang, Bluemke David A, Kachenoura Nadjia, Redheuil Alban, Lima João A C, Ambale-Venkatesh Bharath
Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
National Institutes of Health, Bethesda, MD 20892, USA.
J Clin Med. 2023 Aug 1;12(15):5062. doi: 10.3390/jcm12155062.
. Chronic inflammation is associated with incident cardiovascular events. We study the association between biomarkers of inflammation and subclinical vascular dysfunction measured as proximal aortic stiffness. MRI imaging was performed in the Multi-Ethnic Study of Atherosclerosis (MESA) at baseline (2000) and at the 10-year follow-up. Aortic arch pulse wave velocity (PWV) and ascending and descending aorta distensibility (AAD, DAD) were measured in 1223 asymptomatic individuals at both exams. Linear regression was used to study the association of baseline inflammation-C-reactive protein (CRP), interleukin-6 (IL6), and fibrinogen (Fib)-with baseline and 10-year changes in aortic stiffness (PWV, AAD, DAD). . The mean age of the participants was 59 ± 9 years, 47.8% of them were men, 32.6% were hypertensive at baseline, and 7.6% were diabetic. At baseline and follow-up, the mean AAD values were, respectively, 1.73 × 10 mmHg and 1.57 × 10 mmHg, the mean DAD values were 2.19 × 10 mmHg and 1.99 × 10 mmHg, and the mean PWV values were 8.10 m/s and 8.99 m/s. At baseline, the AAD (in 10 mmHg) and DAD (in 10 mmHg) were inversely associated with CRP (in mg/L) (AAD coeff: -0.047, -value: 0.011, DAD coeff: -0.068, -value: <0.001) and IL6 (in pg/mL) (AAD coeff: -0.098, -value: 0.003, DAD coeff: -0.14, -value: <0.001) in a univariable analysis but not after adjustment for demographic variables or cardiovascular risk factors. The baseline DAD was inversely associated with Fib (in mg/dL) (coeff: -0.334, -value: 0.001). The baseline PWV (in m/s) was positively associated with IL6 (in pg/mL) in a univariable analysis (coeff: 0.054, -value: 0.014). In a longitudinal analysis, the 10-year changes in DAD were inversely associated with CRP, even after adjustment for demographics and risk factors (DAD coeff: -0.08, -value 0.044). Higher CRP levels at baseline were independently associated with a 10-year increase in aortic stiffness, measured as decreased aortic distensibility.
慢性炎症与心血管事件的发生有关。我们研究炎症生物标志物与以近端主动脉僵硬度衡量的亚临床血管功能障碍之间的关联。在动脉粥样硬化多民族研究（MESA）中于基线期（2000年）和10年随访时进行了MRI成像。在两次检查中对1223名无症状个体测量了主动脉弓脉搏波速度（PWV）以及升主动脉和降主动脉的扩张性（AAD、DAD）。使用线性回归研究基线炎症标志物——C反应蛋白（CRP）、白细胞介素-6（IL6）和纤维蛋白原（Fib）——与主动脉僵硬度（PWV、AAD、DAD）的基线变化和10年变化之间的关联。参与者的平均年龄为59±9岁，其中47.8%为男性，32.6%在基线时患有高血压，7.6%患有糖尿病。在基线期和随访时，平均AAD值分别为1.73×10 mmHg和1.57×10 mmHg，平均DAD值分别为2.19×10 mmHg和1.99×10 mmHg，平均PWV值分别为8.10 m/s和8.99 m/s。在基线时，单变量分析中AAD（单位为10 mmHg）和DAD（单位为10 mmHg）与CRP（单位为mg/L）呈负相关（AAD系数：-0.047，P值：0.011，DAD系数：-0.068，P值：<0.001）以及与IL6（单位为pg/mL）呈负相关（AAD系数：-0.098，P值：0.003，DAD系数：-0.14，P值：<0.001），但在对人口统计学变量或心血管危险因素进行调整后则不然。基线DAD与Fib（单位为mg/dL）呈负相关（系数：-0.334，P值：0.001）。单变量分析中基线PWV（单位为m/s）与IL6（单位为pg/mL）呈正相关（系数：0.054，P值：0.014）。在纵向分析中，即使对人口统计学和危险因素进行了调整，DAD的10年变化仍与CRP呈负相关（DAD系数：-0.
