Starzyński Dariusz, Rzeszotek Sylwia, Kolasa Agnieszka, Grabowska Marta, Wiszniewska Barbara, Kudrymska Aleksandra, Karpińska Katarzyna, Tołoczko-Grabarek Aleksandra, Janiec Agnieszka, Myszka Aleksandra, Rynio Paweł, Syrenicz Anhelli, Sowińska-Przepiera Elżbieta
Department of Endocrinology, Metabolic and Internal Diseases, Faculty of Medicine and Dentistry, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 70-252 Szczecin, Poland.
Department of Histology and Embryology, Faculty of Medicine and Dentistry, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72, 70-111 Szczecin, Poland.
J Clin Med. 2023 Aug 2;12(15):5086. doi: 10.3390/jcm12155086.
Appendix neuroendocrine neoplasm (ANEN) treatment is based on tumor size and proliferation markers. Recently, the role of the follicle-stimulating hormone receptor (FSHR) from the clinical perspective has also been increasingly discussed. The FSHR is expressed in the endothelial cells of both intratumoral and peritumoral blood vessels, where it contributes to neoangiogenesis and blood vessel remodeling. FSHR expression is associated with a range of tumor types, such as gastrointestinal tumors, and it is not detected in healthy tissues located more than 10 mm from the tumor site or in tumor lymphatics. In this study, we evaluated the expression of FSHR and CD31 in the blood vessels of ANENs in females and males with confirmed histopathology. We conducted a quantitative analysis of the immunohistochemical reactions and found a higher number of microvessels in the mucosa and submucosa of neuroendocrine tumors in the appendix. A higher level of FSHR expression was observed in women. Future research should consider whether an elevated number of blood vessels along with a strong pattern of FSHR expression may influence future treatment strategies.
阑尾神经内分泌肿瘤（ANEN）的治疗基于肿瘤大小和增殖标志物。最近，从临床角度对促卵泡激素受体（FSHR）的作用也进行了越来越多的讨论。FSHR在肿瘤内和肿瘤周围血管的内皮细胞中表达，它有助于新血管生成和血管重塑。FSHR表达与一系列肿瘤类型相关，如胃肠道肿瘤，在距离肿瘤部位超过10毫米的健康组织或肿瘤淋巴管中未检测到。在本研究中，我们评估了经组织病理学确诊的女性和男性ANENs血管中FSHR和CD31的表达。我们对免疫组化反应进行了定量分析，发现阑尾神经内分泌肿瘤的黏膜和黏膜下层微血管数量较多。在女性中观察到较高水平的FSHR表达。未来的研究应考虑血管数量增加以及FSHR表达强烈模式是否可能影响未来的治疗策略。
