Florêncio Gisele, Souza Aglécio, Chaim Elinton, Santos Allan, Duran Louise, Carvalho Camila, Monte Alegre Sarah
Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas 13083-887, Brazil.
Department of Surgery, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas 13083-887, Brazil.
J Clin Med. 2023 Aug 4;12(15):5124. doi: 10.3390/jcm12155124.
Sarcopenic obesity is characterized by a disproportion between the amount of muscle to fat. Contrary to most studies evaluating parameters related to sarcopenic obesity in the elderly, this study aims to evaluate the phase angle (PhA) and sarcopenia in young individuals pre- and post-Roux-en-Y gastric bypass. A total of 69 volunteers (46 women and 23 men; 38.5 ± 8.1 years) participated in this study. Body composition and PhA were assessed using BIA. Sarcopenia was assessed using a handgrip strength test (HGS) and gait speed (GS), and appendicular lean mass (ALM) was assessed using Dual Energy X-ray Absorptiometry (DXA). The PhA was significantly lower ( < 0.0007) and the resistance (R) significantly higher ( = 0.0026) in the postoperative group. HGS was negatively correlated with R (r = -0.63669; < 0.0001), hs-CRP (r = -0.45436; = 0.0197), and leptin (r = -0.46505; = 0.0043). GS was negatively correlated with R (r = -0.36220; = 0.0254), and ALM was negatively correlated with reactance (r = -0.49485; = 0.0034) and R (r = -0.65797; ≤ 0.0001). PhA and other components of BIA provide a good correlation with sarcopenia, especially regarding the reduction in muscle function, in an early form, in individuals in the pre- and postoperative period of gastric bypass.
肌少症肥胖的特征是肌肉量与脂肪量不成比例。与大多数评估老年人肌少症肥胖相关参数的研究不同，本研究旨在评估青年个体在Roux-en-Y胃旁路手术前后的相位角（PhA）和肌少症。共有69名志愿者（46名女性和23名男性；年龄38.5±8.1岁）参与了本研究。使用生物电阻抗分析（BIA）评估身体成分和PhA。使用握力测试（HGS）和步速（GS）评估肌少症，使用双能X线吸收法（DXA）评估四肢瘦体重（ALM）。术后组的PhA显著降低（<0.0007），电阻（R）显著升高（=0.0026）。HGS与R呈负相关（r = -0.63669；<0.0001）、与超敏C反应蛋白（hs-CRP）呈负相关（r = -0.45436；=0.0197）、与瘦素呈负相关（r = -0.46505；=0.0043）。GS与R呈负相关（r = -0.36220；=0.0254），ALM与电抗呈负相关（r = -0.49485；=0.0034）、与R呈负相关（r = -0.65797；≤0.0001）。在胃旁路手术的术前和术后阶段，个体的PhA和BIA的其他成分与肌少症具有良好的相关性，尤其是在早期形式的肌肉功能下降方面。
