Malinowska Justyna, Małecka-Giełdowska Milena, Pietrucha Katarzyna, Górska Gabriela, Kogut Dagmara, Ciepiela Olga
Department of Laboratory Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland.
Doctoral School, Medical University of Warsaw, 02-091 Warsaw, Poland.
J Clin Med. 2023 Aug 7;12(15):5157. doi: 10.3390/jcm12155157.
(1) Background: The massive transfusion of packed red blood cells (RBCs) is a lifesaving procedure, but it is associated with complications, e.g., dysmagnesemia. Since magnesium is an intracellular ion, the transfused RBCs can significantly influence the magnesium concentration in the recipient's blood. (2) Methods: A retrospective study was performed among 49 patients hospitalized in the Central Clinical Hospital of the Medical University of Warsaw who received a massive blood transfusion (≥4 units/h). Data on laboratory results and patient history were collected from the hospital database. The intracellular RBCs magnesium concentration was measured in 231 samples using the colorimetric method. (3) Results: There were statistically significant changes in the mean serum magnesium concentration preoperatively and 24 h postoperatively (0.87 ± 0.13 vs. 1.03 ± 0.14, < 0.00001) and 48 h postoperatively (0.87 ± 0.13 vs. 1.06 ± 0.15, < 0.00001). Patients who died had significantly higher serum magnesium concentrations ( < 0.05). The median intracellular magnesium concentration in RBCs was 0.91 (0.55-1.8) mmol/L, which is below the reference values of 1.65-2.65 mmol/L. (4) Conclusions: Transfused RBCs significantly increased the serum magnesium concentration 24 h and 48 h postoperatively. It could be a result of mild hemolysis, as the median intracellular magnesium concentration in RBCs was below the reference values.
(1) 背景：大量输注浓缩红细胞是一种挽救生命的操作，但它会引发并发症，例如镁缺乏血症。由于镁是一种细胞内离子，输注的红细胞会显著影响受血者血液中的镁浓度。(2) 方法：对在华沙医科大学中央临床医院住院的49例接受大量输血（≥4单位/小时）的患者进行了一项回顾性研究。从医院数据库收集了实验室检查结果和患者病史数据。采用比色法对231份样本中的红细胞内镁浓度进行了测量。(3) 结果：术前和术后24小时平均血清镁浓度有统计学显著变化（0.87±0.13对1.03±0.14，<0.00001）以及术后48小时（0.87±0.13对1.06±0.15，<0.00001）。死亡患者的血清镁浓度显著更高（<0.05）。红细胞内镁浓度的中位数为0.91（0.55 - 1.8）mmol/L，低于1.65 - 2.65 mmol/L的参考值。(4) 结论：输注的红细胞在术后24小时和48小时显著提高了血清镁浓度。这可能是轻度溶血的结果，因为红细胞内镁浓度的中位数低于参考值。
