大鼠神经母细胞瘤的交感神经系统营养作用及其年龄依赖性
Sympathetic nervous system trophism for neuroblastoma and its age dependence in rats.
作者信息
Chelmicka-Schorr E, Checinski M E, Jones K H, Yu R C, Arnason B G
出版信息
Cancer Res. 1986 Nov;46(11):5504-6.
PMID:3756898
Abstract
The sympathetic nervous system modulates the growth of C-1300 mouse neuroblastoma in vivo and in vitro. We now report that a mitogenic/trophic factor that augments growth of C-1300 neuroblastoma and of the S-20 neuroblastoma clonal line is present in freshly excised sympathetic cervical ganglia from newborn rats, but is not detectable in homogenates from sympathetic ganglia obtained from adult rats.
摘要
交感神经系统在体内和体外调节C - 1300小鼠神经母细胞瘤的生长。我们现在报告，一种促有丝分裂/营养因子存在于新生大鼠新鲜切除的颈交感神经节中，它能促进C - 1300神经母细胞瘤和S - 20神经母细胞瘤克隆系的生长，但在成年大鼠交感神经节的匀浆中检测不到。
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