重氮醌对白血病L1210细胞的光敏作用。
Photosensitization of leukemia L1210 cells with diaziquone.
作者信息
Kessel D, Thompson P
出版信息
Cancer Res. 1986 Nov;46(11):5587-8.
PMID:3756904
Abstract
Exposure of leukemia L1210 cells in culture to the drug diaziquone resulted in inhibition of incorporation of labeled thymidine into nucleic acid and loss of cell viability. These effects were markedly potentiated by irradiation of cells previously exposed to diaziquone in culture. This result shows that diaziquone can catalyze phototoxicity; the action spectrum of the drug may limit clinical applications of this phenomenon.
摘要
将培养中的白血病L1210细胞暴露于药物重氮醌会导致标记的胸苷掺入核酸受到抑制以及细胞活力丧失。这些效应在对培养中先前暴露于重氮醌的细胞进行照射后显著增强。这一结果表明重氮醌可催化光毒性；该药物的作用光谱可能会限制这一现象的临床应用。
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