Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Department of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.
Yale J Biol Med. 2020 Mar 27;93(1):97-110. eCollection 2020 Mar.
Psoriasis is a frequent inflammatory skin disease. Fundamental research on the pathogenesis of psoriasis has substantially increased our understanding of skin immunology, which has helped to introduce innovative and highly effective therapies. Psoriasis is a largely T lymphocyte-mediated disease in which activation of innate immune cells and pathogenic T cells result in skin inflammation and hyperproliferation of keratinocytes. B cells have thus far largely been neglected regarding their role for the pathogenesis of psoriasis. However, recent data shed light on their role in inflammatory skin diseases. Interestingly, interleukin (IL)-10-producing regulatory B cells have been assumed to ameliorate psoriasis. In this review, we will discuss the development of disease, pathogenicity, and current developments in therapeutic options. We describe different roles of T cells, B cells, and cytokines for the immunopathology and disease course of psoriasis.
银屑病是一种常见的炎症性皮肤病。对银屑病发病机制的基础研究极大地提高了我们对皮肤免疫学的认识，这有助于引入创新和高效的治疗方法。银屑病在很大程度上是一种 T 淋巴细胞介导的疾病，其中先天免疫细胞和致病 T 细胞的激活导致皮肤炎症和角质形成细胞的过度增殖。迄今为止，B 细胞在银屑病发病机制中的作用在很大程度上被忽视了。然而，最近的数据揭示了它们在炎症性皮肤病中的作用。有趣的是，产生白细胞介素 (IL)-10 的调节性 B 细胞被认为可以改善银屑病。在这篇综述中，我们将讨论疾病的发展、发病机制和治疗选择的最新进展。我们描述了 T 细胞、B 细胞和细胞因子在银屑病的免疫病理学和疾病过程中的不同作用。
