Ekeuku Sophia Ogechi, Mohd Murshid Nuraqila, Shukri Siti Nursyazwani, Mohd Sahardi Nur Fatin Nabilah, Makpol Suzana
Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Level 17, Preclinical Building, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia.
Int J Mol Sci. 2023 Aug 3;24(15):12372. doi: 10.3390/ijms241512372.
Research into ageing is focused on understanding why some people can maintain cognitive ability and others lose autonomy, affecting their quality of life. Studies have revealed that age-related neurodegenerative disorders like Alzheimer's disease (AD) are now major causes of death among the elderly, surpassing malignancy. This review examines the effects of vitamin E on transcriptomic changes in ageing and neurodegenerative diseases, using AD as an example, and how different transcriptome profiling techniques can shape the results. Despite mixed results from transcriptomic studies on AD patients' brains, we think advanced technologies could offer a more detailed and accurate tool for such analysis. Research has also demonstrated the role of antioxidant modifiers in preventing AD. This review will explore the key findings regarding AD and its modulation by vitamin E, emphasizing the shift in its epidemiology during the ageing process.
对衰老的研究聚焦于理解为何有些人能够保持认知能力，而另一些人则丧失自主能力，影响其生活质量。研究表明，像阿尔茨海默病（AD）这样与年龄相关的神经退行性疾病如今已成为老年人死亡的主要原因，超过了恶性肿瘤。本综述以AD为例，探讨维生素E对衰老和神经退行性疾病中转录组变化的影响，以及不同的转录组分析技术如何影响结果。尽管对AD患者大脑进行转录组研究的结果不一，但我们认为先进技术可为这类分析提供更详细、准确的工具。研究还证明了抗氧化修饰剂在预防AD方面的作用。本综述将探讨关于AD及其受维生素E调节的关键发现，强调其在衰老过程中流行病学的转变。
