Szczuka Joanna, Sandomierski Mariusz, Voelkel Adam, Grochalski Karol, Buchwald Tomasz
Institute of Materials Research and Quantum Engineering, Poznan University of Technology, 60-965 Poznan, Poland.
Institute of Chemical Technology and Engineering, Poznan University of Technology, 60-965 Poznan, Poland.
Materials (Basel). 2023 Aug 1;16(15):5404. doi: 10.3390/ma16155404.
With the simultaneous increase in the number of endoprostheses being performed, advances in the field of biomaterials are becoming apparent-whereby the materials and technologies used to construct implants clearly improve the implants' quality and, ultimately, the life of the patient after surgery. The aim of this study was to modify the titanium alloy Ti6Al4V ELI used in the construction of hip joint endoprostheses. This is why the continuous development of biomaterials is so important. This paper presents the results of research for a new application of polymer poly(ethylene-alt-maleic anhydride) as a drug release layer, placed on the surface of a titanium alloy. The obtained layers were analyzed using Raman spectroscopy (spectra and maps), Fourier transform infrared spectroscopy (spectra and maps), contact angle measurements as well as scanning electron microscopy and energy dispersive spectroscopy imaging and topography analysis. The results confirmed that the polymer layer obtained on the plate surface after the alkali heat treatment process is much better-it binds much more polymer and thus the applied drug. In addition, a longer and more gradual release of the drug was observed for the alkali heat treatment modification than for HO solution.
随着进行的内置假体数量同时增加，生物材料领域的进展日益明显——用于构建植入物的材料和技术明显提高了植入物的质量，并最终改善了患者术后的生活。本研究的目的是对用于构建髋关节内置假体的钛合金Ti6Al4V ELI进行改性。这就是生物材料持续发展如此重要的原因。本文介绍了将聚合物聚（乙烯-alt-马来酸酐）作为药物释放层应用于钛合金表面的新研究结果。使用拉曼光谱（光谱和图谱）、傅里叶变换红外光谱（光谱和图谱）、接触角测量以及扫描电子显微镜和能量色散光谱成像与形貌分析对所得层进行了分析。结果证实，经过碱热处理过程后在板材表面获得的聚合物层要好得多——它结合了更多的聚合物以及因此结合了更多的应用药物。此外，与用HO溶液处理相比，观察到碱热处理改性的药物释放时间更长且更平缓。
