基于高含量α-磷酸三钙的聚-3-羟基丁酸酯的非织造纤维材料的开发。

Development of Nonwoven Fibrous Materials Based on Poly-3-Hydroxybutyrate with a High Content of α-Tricalcium Phosphate.

作者信息

Tyubaeva Polina M, Gasparyan Kristina G, Fedotov Alexander Yu, Lobzhanidze Pavel V, Baranov Oleg V, Egorov Alexey A, Sirotinkin Vladimir P, Komlev Vladimir S, Olkhov Anatoly A

机构信息

Department of Physical Chemistry of Synthetic and Natural Polymer Compositions, Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 Kosygina Street, 119334 Moscow, Russia.

Academic Department of Innovational Materials and Technologies Chemistry, Plekhanov Russian University of Economics, 36 Stremyanny Per., 117997 Moscow, Russia.

出版信息

Polymers (Basel). 2023 Jul 26;15(15):3167. doi: 10.3390/polym15153167.

DOI:10.3390/polym15153167

PMID:37571064

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10421182/

Abstract

α-tricalcium (α-TCP) phosphate is widely used as an osteoinductive biocompatible material, serving as an alternative to synthetic porous bone materials. The objective of this study is to obtain a highly filled fibrous nonwoven material composed of poly-3-hydroxybutyrate (PHB) and α-TCP and to investigate the morphology, structure, and properties of the composite obtained by the electrospinning method (ES). The addition of α-TCP had a significant effect on the supramolecular structure of the material, allowing it to control the crystallinity of the material, which was accompanied by changes in mechanical properties, FTIR spectra, and XRD curves. The obtained results open the way to the creation of new osteoconductive materials with a controlled release of the source of calcium into the living organism.

摘要

α-磷酸三钙（α-TCP）作为一种骨诱导生物相容性材料被广泛应用，可作为合成多孔骨材料的替代品。本研究的目的是获得一种由聚-3-羟基丁酸酯（PHB）和α-TCP组成的高填充纤维非织造材料，并研究通过静电纺丝法（ES）制备的复合材料的形态、结构和性能。α-TCP的添加对材料的超分子结构有显著影响，使其能够控制材料的结晶度，同时伴随着机械性能、傅里叶变换红外光谱（FTIR）和X射线衍射（XRD）曲线的变化。所得结果为制备新型骨传导材料开辟了道路，这种材料能够将钙源可控地释放到生物体内。