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用于医疗应用的体温响应型热固性形状记忆聚氨酯的制备与表征

Preparation and Characterization of Body-Temperature-Responsive Thermoset Shape Memory Polyurethane for Medical Applications.

作者信息

Yang Xiaoqing, Han Zhipeng, Jia Chengqi, Wang Tianjiao, Wang Xiaomeng, Hu Fanqi, Zhang Hui, Zhao Jun, Zhang Xuesong

机构信息

Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.

Department of Orthopaedics, The Fourth Medical Centre, Chinese PLA General Hospital, Beijing 100048, China.

出版信息

Polymers (Basel). 2023 Jul 27;15(15):3193. doi: 10.3390/polym15153193.

DOI:10.3390/polym15153193
PMID:37571087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10420975/
Abstract

Shape memory polymers (SMPs) are currently one of the most attractive smart materials expected to replace traditional shape memory alloys and ceramics (SMAs and SMCs, respectively) in some fields because of their unique properties of high deformability, low density, easy processing, and low cost. As one of the most popular SMPs, shape memory polyurethane (SMPU) has received extensive attention in the fields of biomedicine and smart textiles due to its biocompatibility and adjustable thermal transition temperature. However, its laborious synthesis, limitation to thermal response, poor conductivity, and low modulus limit its wider application. In this work, biocompatible poly(ε-caprolactone) diol (PCL-2OH) is used as the soft segment, isophorone diisocyanate (IPDI) is used as the hard segment, and glycerol (GL) is used as the crosslinking agent to prepare thermoset SMPU with a thermal transition temperature close to body temperature for convenient medical applications. The effects of different soft-chain molecular weights and crosslinking densities on the SMPU's properties are studied. It is determined that the SMPU has the best comprehensive performance when the molar ratio of IPDI:PCL-2OH:GL is 2:1.5:0.33, which can trigger shape memory recovery at body temperature and maintain 450% recoverable strain. Such materials are excellent candidates for medical devices and can make great contributions to human health.

摘要

形状记忆聚合物（SMPs）是目前最具吸引力的智能材料之一，由于其具有高可变形性、低密度、易于加工和低成本等独特性能，有望在某些领域取代传统的形状记忆合金和陶瓷（分别为SMAs和SMCs）。作为最受欢迎的SMPs之一，形状记忆聚氨酯（SMPU）因其生物相容性和可调节的热转变温度，在生物医学和智能纺织品领域受到了广泛关注。然而，其合成过程繁琐、热响应受限、导电性差和模量低等问题限制了其更广泛的应用。在这项工作中，使用生物相容性聚（ε-己内酯）二醇（PCL-2OH）作为软段，异佛尔酮二异氰酸酯（IPDI）作为硬段，甘油（GL）作为交联剂，制备热转变温度接近体温的热固性SMPU，以方便医疗应用。研究了不同软链分子量和交联密度对SMPU性能的影响。确定当IPDI:PCL-2OH:GL的摩尔比为2:1.5:0.33时，SMPU具有最佳的综合性能，其可在体温下触发形状记忆恢复，并保持450%的可恢复应变。这类材料是医疗设备的理想候选材料，可为人类健康做出巨大贡献。

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