Shi Jiaxin, Xia Fei, Tu Qingchao, Wang Chen, Wang Zhiqi, Li Bo, Guo Baohua, Qiu Chong, Xu Jun
Advanced Materials Laboratory of Ministry of Education (MOE), Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Sci Adv. 2025 Jun 13;11(24):eadv4646. doi: 10.1126/sciadv.adv4646.
The integration of high strength, super toughness, damage resistance, body-temperature shape memory, and biosafety into a single skin-mimic material system has been a notable challenge in the realm of material science and biomedical applications. In this study, "Lego-like" polyurethane (PU) was selected to amalgamate multiple properties through the design of multilevel structures. By comprehensively designing the chemical and sequence structures of blocks, coordinating weak/strong hydrogen bonds, and achieving rational microphase separation and crystallization, an elastomer was obtained with an exceptional true tensile strength of 1.42 gigapascal, a high fracture energy of 384.7 ± 18.9 kJ/m, and a skin-like nonlinear mechanoresponse. The coordination of crystallization and physical cross-linking also guaranteed excellent body-temperature shape memory properties, which are applicable in 4D printing. Moreover, the obtained elastomer is biosafe and has the potential to promote cell proliferation and DNA repair, which will find wide applications in the biomedical field including minimally invasive surgery.
将高强度、超高韧性、抗损伤性、体温形状记忆和生物安全性集成到单一的仿皮肤材料系统中，一直是材料科学和生物医学应用领域的一项重大挑战。在本研究中，选择了“乐高积木式”聚氨酯（PU），通过多级结构设计来融合多种性能。通过全面设计嵌段的化学和序列结构、协调弱/强氢键以及实现合理的微相分离和结晶，获得了一种弹性体，其具有1.42吉帕斯卡的出色真实拉伸强度、384.7±18.9 kJ/m的高断裂能以及类似皮肤的非线性力学响应。结晶与物理交联的协同作用还确保了优异的体温形状记忆性能，适用于4D打印。此外，所获得的弹性体具有生物安全性，并有促进细胞增殖和DNA修复的潜力，这将在包括微创手术在内的生物医学领域得到广泛应用。
