Xu Feng, Wen Yawei, Hu Xinge, Wang Tiannan, Chen Guoxun
Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Department of Nutrition, University of Tennessee at Knoxville, Knoxville, TN 37996, USA.
Diseases. 2021 Jun 28;9(3):46. doi: 10.3390/diseases9030046.
The newly found SARS-CoV-2 has led to the pandemic of COVID-19, which has caused respiratory distress syndrome and even death worldwide. This has become a global public health crisis. Unfortunately, elders and subjects with comorbidities have high mortality rates. One main feature of COVID-19 is the cytokine storm, which can cause damage in cells and tissues including the kidneys. Here, we reviewed the current literature on renal impairments in patients with COVID-19 and analyzed the possible etiology and mechanisms. In addition, we investigated the potential use of vitamin C for the prevention of renal injury in those patients. It appears that vitamin C could be helpful to improve the outcomes of patients with COVID-19. Lastly, we discussed the possible protective effects of vitamin C on renal functions in COVID-19 patients with existing kidney conditions.
新发现的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）导致了2019冠状病毒病（COVID-19）大流行，该病在全球范围内引发了呼吸窘迫综合征甚至死亡。这已成为一场全球公共卫生危机。不幸的是，老年人和患有合并症的患者死亡率很高。COVID-19的一个主要特征是细胞因子风暴，它可导致包括肾脏在内的细胞和组织损伤。在此，我们回顾了关于COVID-19患者肾功能损害的当前文献，并分析了可能的病因和机制。此外，我们研究了维生素C在预防这些患者肾损伤方面的潜在用途。看来维生素C可能有助于改善COVID-19患者的预后。最后，我们讨论了维生素C对已有肾脏疾病的COVID-19患者肾功能可能的保护作用。
