Department of Bioinformatics and Genomics, University of North Carolina, Charlotte, NC 28223, USA.
Department of Pharmaceutical Sciences, College of Health Professions, North Dakota State University, Fargo, ND 58103, USA.
Nutrients. 2023 Jul 26;15(15):3323. doi: 10.3390/nu15153323.
Metabolic and bariatric surgery (MBS) is the most effective long-term treatment for Class III obesity. Reduced dietary intake is considered a behavioral driver of post-surgical weight loss, but limited data have examined this association. Therefore, this study examined prospective, longitudinal relationships between dietary intake and weight loss over 24 months following Roux-en-Y Gastric Bypass and Sleeve Gastrectomy. Relationships between weight loss and dietary intake were examined using a validated 24-h dietary recall method. Associations between total energy/macronutrient intake and weight loss outcomes were assessed at 12-, 18-, and 24-months following MBS, defining patients as "responders" and "suboptimal responders". Consistent with previous literature, 12-month responders and suboptimal responders showed significant associations between weight loss and energy ( = 0.018), protein ( = 0.002), and total fat intake ( = 0.005). However, this study also revealed that many of these associations are no longer significant 24 months post-MBS ( > 0.05), despite consistent weight loss trends. This study suggests a short-term signal between these dietary factors and weight loss outcomes 12 months post-MBS; however, this signal does not persist beyond 12 months. These results are essential for interpreting and designing clinical studies measuring long-term post-surgical weight loss outcomes.
代谢与减重手术（MBS）是治疗 III 类肥胖的最有效长期手段。减少饮食摄入被认为是术后体重减轻的行为驱动因素，但有限的数据研究了这种关联。因此，本研究使用经过验证的 24 小时饮食回忆法，检查了 Roux-en-Y 胃旁路术和袖状胃切除术 24 个月后饮食摄入与体重减轻之间的前瞻性、纵向关系。通过 12、18 和 24 个月的 MBS 评估总能量/宏量营养素摄入量与体重减轻结果之间的关联，将患者定义为“应答者”和“非最佳应答者”。与先前的文献一致，12 个月的应答者和非最佳应答者显示体重减轻与能量（ = 0.018）、蛋白质（ = 0.002）和总脂肪摄入（ = 0.005）之间存在显著关联。然而，本研究还表明，尽管体重减轻趋势一致，但这些关联在 MBS 后 24 个月时不再具有统计学意义（ > 0.05）。这项研究表明，在 MBS 后 12 个月，这些饮食因素与体重减轻结果之间存在短期信号；然而，这种信号不会持续超过 12 个月。这些结果对于解释和设计测量长期术后体重减轻结果的临床研究至关重要。
