Custers Emma, van der Burgh Yonta G R, Vreeken Debby, Schuren Frank, van den Broek Tim J, Verschuren Lars, de Blaauw Ivo, Bouwens Mark, Kleemann Robert, Kiliaan Amanda J, Hazebroek Eric J
Department of Bariatric Surgery, Vitalys, Rijnstate Hospital, Arnhem, the Netherlands.
Department of Medical Imaging, Anatomy, Radboud University Medical Center, Radboud Alzheimer Center, Donders Institute for Brain Cognition and Behaviour, Center for Medical Neuroscience, Nijmegen, the Netherlands.
Heliyon. 2024 Oct 31;10(21):e39899. doi: 10.1016/j.heliyon.2024.e39899. eCollection 2024 Nov 15.
Unexplainable gastrointestinal complaints occasionally occur after Roux-en-Y Gastric Bypass (RYGB) surgery. We therefor investigated the impact of microbiota composition and metabolites on gastrointestinal complaints after RYGB. In the BARICO study (Bariatric surgery Rijnstate and Radboudumc neuroimaging and Cognition in Obesity), microbiota and metabolites were measured before surgery, and 6, and 24 months after surgery. Gastrointestinal complaints were assessed with the Irritable Bowel Syndrome Severity Scoring System (IBS-SSS) questionnaire 24 months after surgery. 65 participants (86.2 % female) with a mean age of 46.2 ± 6.0 years, and mean BMI of 41.2 ± 3.6 kg/m were included. According to the IBS-SSS questionnaire, 32.3 % had moderate/severe gastrointestinal complaints 24 months after surgery. Microbiota alpha diversity remained stable, while beta diversity significantly changed over time. Bile acids and short-chain fatty acids were significantly higher, and inflammatory markers significantly lower after surgery. sp., / sp., and correlated positively, while sp correlated inversely with gastrointestinal complaints. Patients with mild and moderate/severe gastrointestinal complaints showed higher levels of GLC-3S. These findings suggest involvement of microbiota and metabolite changes in gastrointestinal complaints after surgery. However, it remains unclear whether bacteria influence gastrointestinal complaints directly or indirectly. Further exploration is required for development of interventions against gastrointestinal symptoms after surgery.
胃旁路手术（RYGB）后偶尔会出现无法解释的胃肠道不适。因此，我们研究了微生物群组成和代谢产物对RYGB术后胃肠道不适的影响。在BARICO研究（肥胖症的里恩斯塔特减肥手术和拉德堡大学医学中心神经影像学与认知研究）中，在手术前、术后6个月和24个月测量了微生物群和代谢产物。术后24个月，使用肠易激综合征严重程度评分系统（IBS-SSS）问卷评估胃肠道不适情况。纳入了65名参与者（86.2%为女性），平均年龄为46.2±6.0岁，平均BMI为41.2±3.6kg/m²。根据IBS-SSS问卷，32.3%的参与者在术后24个月有中度/重度胃肠道不适。微生物群的α多样性保持稳定，而β多样性随时间显著变化。术后胆汁酸和短链脂肪酸显著升高，炎症标志物显著降低。某菌属、某菌属和某菌属与胃肠道不适呈正相关，而某菌属与胃肠道不适呈负相关。轻度和中度/重度胃肠道不适的患者显示出较高水平的GLC-3S。这些发现表明微生物群和代谢产物变化与术后胃肠道不适有关。然而，尚不清楚细菌是直接还是间接影响胃肠道不适。需要进一步探索以开发针对术后胃肠道症状的干预措施。
