Ministry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Childhood Nutrition Research Centre, Population, Policy and Practice Research Department, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Nutrients. 2023 Jul 27;15(15):3342. doi: 10.3390/nu15153342.
Early growth has long-lasting associations with adult metabolic health. However, the association of adiposity with cardiometabolic risk factors in toddlers remains poorly understood. This study aimed to examine the association of maternal prenatal factors and child adiposity with child cardiometabolic risk factors among boys and girls aged 2 years. This was a birth cohort study of 549 term-born children in Shanghai, China, with follow-up data at the age of 2-years. Child anthropometric and adiposity measurements included weight, length, and skinfold thickness (triceps, subscapular, and abdominal). Child cardiometabolic risk factors included random morning plasma glucose, serum insulin, lipids, and systolic and diastolic blood pressure (SBP, DBP). At 2 years, overweight/obesity (weight-for-length z score, ZWFL > 2) was associated with 12.6 (95%CI 7.7, 17.4) mmHg higher SBP, and 7.9 (4.1, 11.8) mmHg higher DBP in boys, with similar results observed in girls. Maternal hypertensive disorders of pregnancy were associated with 3.0 (0.1, 5.8) higher SBP, 3.17 (0.90, 5.44) mmHg higher DBP, 0.24 (0.01,0.47) mmol/L higher plasma glucose, and 0.26 (0.01,0.51) mmol/L higher serum triglycerides after adjustment for child age, sex, and ZWFL. Maternal hypertensive disorders of pregnancy and child overweight/obesity were associated with higher SBP and DBP at the age of 2 years.
早期生长与成人代谢健康有着持久的关联。然而，脂肪含量与幼儿心血管代谢危险因素之间的关联仍知之甚少。本研究旨在探讨母亲产前因素和儿童肥胖与男童和女童 2 岁时心血管代谢危险因素之间的关系。这是一项在中国上海进行的 549 名足月出生儿童的队列研究，在 2 岁时进行了随访。儿童人体测量和肥胖测量包括体重、身高和皮褶厚度（三头肌、肩胛下和腹部）。儿童心血管代谢危险因素包括随机早晨血浆葡萄糖、血清胰岛素、血脂和收缩压和舒张压（SBP、DBP）。2 岁时，超重/肥胖（体重身长 Z 评分，ZWFL>2）与男孩的 SBP 升高 12.6（95%CI 7.7, 17.4）mmHg，DBP 升高 7.9（4.1, 11.8）mmHg，女孩也有类似的结果。母亲妊娠高血压疾病与 SBP 升高 3.0（0.1, 5.8）mmHg、DBP 升高 3.17（0.90, 5.44）mmHg、血浆葡萄糖升高 0.24（0.01,0.47）mmol/L、血清甘油三酯升高 0.26（0.01,0.51）mmol/L有关，在调整了儿童年龄、性别和 ZWFL 后。母亲妊娠高血压疾病和儿童超重/肥胖与 2 岁时的 SBP 和 DBP 升高有关。
