State Key Laboratory of Electronic Thin Films and Integrated Devices, School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China (UESTC), Chengdu 610054, China.
Sensors (Basel). 2023 Aug 3;23(15):6910. doi: 10.3390/s23156910.
Dynamic glucose monitoring is important to reduce the risk of metabolic diseases such as diabetes. Wearable biosensors based on organic electrochemical transistors (OECTs) have been developed due to their excellent signal amplification capabilities and biocompatibility. However, traditional wearable biosensors are fabricated on flat substrates with limited gas permeability, resulting in the inefficient evaporation of sweat, reduced wear comfort, and increased risk of inflammation. Here, we proposed breathable OECT-based glucose sensors by designing a porous structure to realize optimal breathable and stretchable properties. The gas permeability of the device and the relationship between electrical properties under different tensile strains were carefully investigated. The OECTs exhibit exceptional electrical properties (g ~1.51 mS and I ~0.37 mA) and can retain up to about 44% of their initial performance even at 30% stretching. Furthermore, obvious responses to glucose have been demonstrated in a wide range of concentrations (10-10 M) even under 30% strain, where the normalized response to 10 M is 26% and 21% for the pristine sensor and under 30% strain, respectively. This work offers a new strategy for developing advanced breathable and wearable bioelectronics.
动态血糖监测对于降低糖尿病等代谢性疾病的风险非常重要。基于有机电化学晶体管 (OECT) 的可穿戴生物传感器由于其出色的信号放大能力和生物相容性而得到了发展。然而，传统的可穿戴生物传感器是在透气性有限的平面衬底上制造的，这导致汗液蒸发效率低下、穿着舒适性降低以及炎症风险增加。在这里，我们通过设计多孔结构来实现最佳的透气和可拉伸性，提出了基于透气 OECT 的葡萄糖传感器。我们仔细研究了器件的透气性和不同拉伸应变下电性能之间的关系。OECT 表现出优异的电性能（g1.51 mS 和 I0.37 mA），即使在 30%的拉伸应变下，仍能保持约 44%的初始性能。此外，即使在 30%的应变下，该传感器在很宽的浓度范围内（10-10 M）也表现出明显的葡萄糖响应，其中对 10 M 葡萄糖的归一化响应分别为原始传感器的 26%和 21%。这项工作为开发先进的透气和可穿戴生物电子学提供了一种新策略。
