Department of Toxicology, School of Public Health, Jilin University, Changchun, Jilin Province, China.
Rev Environ Health. 2023 Aug 14;39(4):721-727. doi: 10.1515/reveh-2022-0104. Print 2024 Dec 17.
Environmental pollution with heavy metals is widespread, thus increasing attention has been paid to their toxic effects. Recent studies have suggested that heavy metals may influence the expression of circadian clock genes. Almost all organs and tissues exhibit circadian rhythms. The normal circadian rhythm of an organism is maintained by the central and peripheral circadian clock. Thus, circadian rhythm disorders perturb normal physiological processes. Here, we review the effects of heavy metals, including manganese, copper, cadmium, and lead, on four core circadian clock genes, i.e., , , , and genes.
重金属污染广泛存在，因此其毒性作用受到越来越多的关注。最近的研究表明，重金属可能会影响生物钟基因的表达。几乎所有的器官和组织都表现出昼夜节律。生物钟的正常昼夜节律由中枢和外周生物钟维持。因此，昼夜节律紊乱会扰乱正常的生理过程。在这里，我们综述了重金属（包括锰、铜、镉和铅）对四个核心生物钟基因，即、、和基因的影响。
