Dredla Brynn K, Del Brutto Oscar H, Castillo Pablo R
Sleep Disorders Center, Mayo Clinic College of Medicine, Jacksonville, FL, USA.
School of Medicine and Research Center, Universidad Espíritu Santo-Ecuador, Samborondón, Ecuador.
Curr Neurol Neurosci Rep. 2023 Oct;23(10):607-615. doi: 10.1007/s11910-023-01293-z. Epub 2023 Aug 12.
The glymphatic system is hypothesized to act as the brain's filtration system to remove toxic solutes that accumulate throughout the day. Perivascular spaces (PVSs) play a fundamental role in the ability of the glymphatic system to function, and sleep influences the effectiveness of this system. This article reviews the complexity of the interplay between sleep, the glymphatic system, and PVS.
New imaging techniques have illuminated the structure of PVS and their associations with differing disease states. Research has shown that sleep may play a key role in the function of PVS and the influence of adenosine, astrocyte, and aquaporin-4 channel in the function of the glymphatic system. Emerging data suggest that differing pathological states such as neuroinflammatory conditions, neurodegenerative diseases, and cognitive dysfunction may be associated with underlying glymphatic system dysfunction, and sleep disorders could be a potential intervention target.
淋巴系统被认为是大脑的过滤系统，用于清除全天积累的有毒溶质。血管周围间隙（PVS）在淋巴系统发挥功能的过程中起着基础性作用，而睡眠会影响该系统的效能。本文综述了睡眠、淋巴系统和血管周围间隙之间复杂的相互作用。
新的成像技术揭示了血管周围间隙的结构及其与不同疾病状态的关联。研究表明，睡眠可能在血管周围间隙的功能以及腺苷、星形胶质细胞和水通道蛋白-4通道对淋巴系统功能的影响中发挥关键作用。新出现的数据表明，不同的病理状态，如神经炎症性疾病、神经退行性疾病和认知功能障碍，可能与潜在的淋巴系统功能障碍有关，而睡眠障碍可能是一个潜在的干预靶点。
