基于基因组的癌症治疗靶点发现。

Genome-guided discovery of cancer therapeutic targets.

作者信息

Konda Prathyusha, Garinet Simon, Van Allen Eliezer M, Viswanathan Srinivas R

机构信息

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.

出版信息

Cell Rep. 2023 Aug 29;42(8):112978. doi: 10.1016/j.celrep.2023.112978. Epub 2023 Aug 10.

DOI:10.1016/j.celrep.2023.112978

PMID:37572322

Abstract

The success of precision oncology-which aims to match the right therapies to the right patients based on molecular status-is predicated on a robust pipeline of molecular targets against which therapies can be developed. Recent advances in genomics and functional genetics have enabled the unbiased discovery of novel molecular targets at scale. We summarize the promise and challenges in integrating genomic and functional genetic landscapes of cancer to establish the next generation of cancer targets.

摘要

精准肿瘤学旨在根据分子状态为合适的患者匹配合适的治疗方法，其成功基于强大的分子靶点库，据此可开发相应治疗方法。基因组学和功能遗传学的最新进展使得能够大规模地无偏见地发现新的分子靶点。我们总结了整合癌症基因组和功能遗传图谱以确立新一代癌症靶点方面的前景与挑战。