Prenatal Diagnosis Center, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen 518033, PR China.
Prenatal Diagnosis Center, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen 518033, PR China.
J Reprod Immunol. 2023 Sep;159:104127. doi: 10.1016/j.jri.2023.104127. Epub 2023 Aug 3.
The Siglecs family is a group of type I sialic acid-binding immunoglobulin-like receptors that regulate cellular signaling by recognizing sialic acid epitopes. Siglecs are predominantly expressed on the surface of leukocytes, where they play a crucial role in regulating immune activity. Pathogens can exploit inhibitory Siglecs by utilizing their sialic acid components to promote invasion or suppress immune functions, facilitating immune evasion. The establishing of an immune-balanced maternal-fetal interface microenvironment is essential for a successful pregnancy. Dysfunctional immune cells may lead to adverse pregnancy outcomes. Siglecs are important for inducing a phenotypic switch in leukocytes at the maternal-fetal interface toward a less toxic and more tolerant phenotype. Recent discoveries regarding Siglecs in the reproductive system have drawn further attention to their potential roles in reproduction. In this review, we primarily discuss the latest advances in understanding the impact of Siglecs as immune regulators on infections and pregnancy.
Siglec 家族是一组 I 型唾液酸结合免疫球蛋白样受体，通过识别唾液酸表位来调节细胞信号转导。Siglecs 主要表达在白细胞表面，在调节免疫活性方面发挥着关键作用。病原体可以利用抑制性 Siglecs，利用它们的唾液酸成分来促进入侵或抑制免疫功能，从而促进免疫逃逸。建立一个免疫平衡的母胎界面微环境对于成功的妊娠是至关重要的。功能失调的免疫细胞可能导致不良的妊娠结局。Siglecs 对于诱导母胎界面白细胞向毒性更小、耐受性更强的表型发生表型转换非常重要。最近在生殖系统中对 Siglecs 的发现进一步引起了人们对它们在生殖中的潜在作用的关注。在这篇综述中，我们主要讨论了关于 Siglecs 作为免疫调节剂对感染和妊娠的影响的最新研究进展。
