Laboratory for Core Technology of TCM Quality Improvement and Transformation, School of Pharmaceutical Science, The Third Affiliated Hospital, Academy of Chinese Medical Science, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
College of Food and Health, Zhejiang A&F University, Hangzhou, 311300, China.
J Ethnopharmacol. 2024 Jan 10;318(Pt B):117022. doi: 10.1016/j.jep.2023.117022. Epub 2023 Aug 10.
Chemotherapy is a common cancer treatment strategy. However, its effectiveness is constrained by toxicity and adverse effects. The Lamiaceae herb Salvia miltiorrhiza Bunge has a long history of therapeutic use in the treatment of blood stasis illnesses, which are believed by traditional Chinese medicine to be connected to cancer.
This review summarized the common toxicity of chemotherapy and the potential chemo-adjuvant effect and mechanisms of active ingredients from S. miltiorrhiza, hoping to provide valuable information for the development and application of S. miltiorrhiza resources.
The literatures were retrieved from PubMed, Web of Science, Baidu Scholar and Google Scholar databases from 2002 to 2022. The inclusion criteria were studies reporting that S. miltiorrhiza or its constituents enhanced the efficiency of chemotherapy drugs or reduced the side effects.
Salvianolic acid A, salvianolic acid B, salvianolic acid C, rosmarinic acid, tanshinone I, tanshinone IIA, cryptotanshinone, dihydrotanshinone I and miltirone are the primary adjuvant chemotherapy components of S. miltiorrhiza. The mechanisms mainly involve inhibiting proliferation, metastasis, and angiogenesis, inducing apoptosis, regulating autophagy and tumor microenvironment. In addition, they also improve chemotherapy drug-induced side effects.
The bioactive compounds of S. miltiorrhiza are shown to inhibit proliferation, metastasis, and angiogenesis, induce apoptosis and autophagy, regulate immunity and tumor microenvironment when combined with chemotherapy drugs. However, further clinical studies are required to validate the current studies.
化疗是一种常见的癌症治疗策略。然而，其疗效受到毒性和不良反应的限制。唇形科植物丹参具有治疗血瘀病的悠久历史，传统中医认为血瘀病与癌症有关。
本综述总结了化疗的常见毒性，以及丹参活性成分的潜在化疗辅助作用和作用机制，希望为丹参资源的开发和应用提供有价值的信息。
文献检索了 2002 年至 2022 年期间 PubMed、Web of Science、百度学术和 Google Scholar 数据库中的文献，纳入标准为报道丹参或其成分增强化疗药物疗效或降低不良反应的研究。
丹参中的主要辅助化疗成分有丹参酸 A、丹参酸 B、丹参酸 C、迷迭香酸、丹参酮 I、丹参酮 IIA、隐丹参酮、二氢丹参酮 I 和紫草酸甲酯。其作用机制主要涉及抑制增殖、转移和血管生成、诱导细胞凋亡、调节自噬和肿瘤微环境。此外，它们还能改善化疗药物引起的不良反应。
丹参的生物活性化合物与化疗药物联合使用时，被证明能抑制增殖、转移和血管生成，诱导细胞凋亡和自噬，调节免疫和肿瘤微环境。然而，还需要进一步的临床研究来验证目前的研究。
