红细胞储存：从基因组到暴露组到个性化输血医学。
Red Blood Cell Storage: From Genome to Exposome Towards Personalized Transfusion Medicine.
机构信息
Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
出版信息
Transfus Med Rev. 2023 Oct;37(4):150750. doi: 10.1016/j.tmrv.2023.150750. Epub 2023 Aug 2.
Over the last decade, the introduction of omics technologies-especially high-throughput genomics and metabolomics-has contributed significantly to our understanding of the role of donor genetics and nongenetic determinants of red blood cell storage biology. Here we briefly review the main advances in these areas, to the extent these contributed to the appreciation of the impact of donor sex, age, ethnicity, but also processing strategies and donor environmental, dietary or other exposures - the so-called exposome-to the onset and severity of the storage lesion. We review recent advances on the role of genetically encoded polymorphisms on red cell storage biology, and relate these findings with parameters of storage quality and post-transfusion efficacy, such as hemolysis, post-transfusion intra- and extravascular hemolysis and hemoglobin increments. Finally, we suggest that the combination of these novel technologies have the potential to drive further developments towards personalized (or precision) transfusion medicine approaches.
在过去的十年中，组学技术的引入——特别是高通量基因组学和代谢组学——极大地促进了我们对供体遗传学和红细胞储存生物学中非遗传决定因素作用的理解。在这里，我们简要回顾了这些领域的主要进展，这些进展在一定程度上有助于了解供体性别、年龄、种族的影响，以及处理策略和供体环境、饮食或其他暴露——所谓的外显子组——对储存损伤的发生和严重程度的影响。我们回顾了最近关于遗传编码多态性对红细胞储存生物学作用的研究进展，并将这些发现与储存质量和输血后疗效的参数相关联，如溶血、输血后血管内和血管外溶血以及血红蛋白增加。最后，我们认为这些新技术的结合有可能推动朝着个性化（或精准）输血医学方法的进一步发展。
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