Division of Infectious Diseases and Immunology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Antivir Chem Chemother. 2023 Jan-Dec;31:20402066231194424. doi: 10.1177/20402066231194424.
Respiratory syncytial virus infections recur throughout life despite induction of immunity by the first natural infection. An effective vaccine has long been sought but no vaccine is currently licensed, although promising candidates are currently being developed based on greater knowledge of the virus properties. However, there are significant populations that may not be protected adequately by a vaccine or are unable to be vaccinated. Thus, there is a continued need for effective therapeutic agents to treat the infection, especially in higher-risk individuals, a perspective presented in this article.
呼吸道合胞病毒感染会在一生中反复发作，尽管第一次自然感染会诱导产生免疫。长期以来一直寻求有效的疫苗，但目前尚未获得许可，尽管目前正在根据对病毒特性的更深入了解开发有前途的候选疫苗。然而，有一些重要的人群可能无法通过疫苗充分保护，或者无法接种疫苗。因此，仍然需要有效的治疗药物来治疗感染，特别是在高危人群中，本文提出了这一观点。
