Department of Engineering, Campus Bio-Medico University, Rome, Italy.
Center for Life Nano- & Neuro-Science (CLN2S@Sapienza), Italian Institute of Technology, Rome, Italy.
Biomol Concepts. 2023 Aug 14;14(1). doi: 10.1515/bmc-2022-0035. eCollection 2023 Jan 1.
Amphid wing "C" (AWC) neurons are among the most important and studied neurons of the nematode In this work, we unify the existing electrical and intracellular calcium dynamics descriptions to obtain a biophysically accurate model of olfactory transduction in AWC neurons. We study the membrane voltage and the intracellular calcium dynamics at different exposure times and odorant concentrations to grasp a complete picture of AWC functioning. Moreover, we investigate the complex cascade of biochemical processes that allow AWC activation upon odor removal. We analyze the behavior of the different components of the models and, by suppressing them selectively, we extrapolate their contribution to the overall neuron response and study the resilience of the dynamical system. Our results are all in agreement with the available experimental data. Therefore, we provide an accurate mathematical and biophysical model for studying olfactory signal processing in
触角翼“C”（AWC）神经元是线虫中最重要和研究最多的神经元之一。在这项工作中，我们将现有的电和细胞内钙动力学描述统一起来，以获得 AWC 神经元嗅觉转导的生物物理精确模型。我们研究了不同暴露时间和气味浓度下的膜电压和细胞内钙动力学，以掌握 AWC 功能的完整图像。此外，我们研究了允许 AWC 在气味去除时激活的复杂生化过程级联。我们分析了模型不同组件的行为，并通过有选择地抑制它们，推断它们对整体神经元反应的贡献，并研究动态系统的弹性。我们的结果都与现有的实验数据一致。因此，我们为研究嗅觉信号处理提供了一个准确的数学和生物物理模型。
