聚甘氨酸修饰玻碳电极灵敏选择性测定解热儿童糖浆中的扑热息痛。
Sensitive and selective determination of paracetamol in antipyretic children's syrup with a polyglycine modified glassy carbon electrode.
机构信息
Necmettin Erbakan University, Institute of Science, Chemistry Department, Konya, Turkiye.
Necmettin Erbakan University, Ahmet Keleşoğlu Education Faculty, Chemistry Department, Konya, Turkiye.
出版信息
Anal Methods. 2023 Aug 24;15(33):4149-4158. doi: 10.1039/d3ay00789h.
A sensitive and selective electrochemical sensor for the determination of paracetamol (acetaminophen) is proposed based on a polyglycine-coated glassy carbon electrode. The electrochemical behavior of paracetamol was studied by cyclic voltammetry and differential pulse voltammetry. Under optimal experimental conditions, the peak oxidation current of paracetamol increases linearly in the range of 0.5-75 μM. The limit of detection of paracetamol was 0.03 μM and the limit of quantitation was 0.09 μM. In addition, modified glassy carbon with polyglycine as the sensor was successfully used for the determination of paracetamol in antipyretic children's syrup samples, with a recovery rate of over 95.3%, showing its great application potential in drug analysis.
基于聚甘氨酸修饰的玻碳电极，提出了一种用于测定扑热息痛（对乙酰氨基酚）的灵敏、选择性电化学传感器。通过循环伏安法和差分脉冲伏安法研究了扑热息痛的电化学行为。在最佳实验条件下，扑热息痛的峰氧化电流在 0.5-75 μM 范围内呈线性增加。扑热息痛的检测限为 0.03 μM，定量限为 0.09 μM。此外，以聚甘氨酸为传感器的修饰玻碳成功用于退热儿童糖浆样品中扑热息痛的测定，回收率超过 95.3%，显示出其在药物分析中具有很大的应用潜力。
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