Department of Gastroenterology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China.
Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China.
Int J Med Sci. 2023 Jul 24;20(9):1144-1151. doi: 10.7150/ijms.84452. eCollection 2023.
Few reports concerning inactivated vaccine efficacy in elderly patients with Omicron infection. We aimed at demonstrating the clinical characteristics of elderly patients with mild disease and assessing the protective effect of the vaccine preliminarily. 13,120 mild patients who aged beyond 60 years old were included in this study totally, medical records were collected and analyzed. Patients beyond 60 years had more chronic comorbidities, significantly lower ORF1ab and N gene CT values, and longer time of nucleic acid conversion than other age groups. Higher CT value of ORF1ab and N gene were found in older patients who received a booster dose of vaccine than in those who received two doses. The time of nucleic acid conversion was longest in unvaccinated old patients, with a decreasing trend from those who received two doses to those who received a booster doses. We also used random forest and logistic regression to screen for factors strongly associated with nucleic acid conversion and to predict the time of nucleic acid conversion. For mild patients with Omicron infection, patients aged>60 years had mild clinical symptoms, higher viral loads, and longer time of nucleic acid conversion, when compared with younger patients. The inactivated SARS-CoV-2 vaccine provided effective protection among adults with omicron variant infection, and the effectiveness of three doses of the vaccine was greater than that of two doses of the vaccine. Special attention should be given to elderly patients.
关于奥密克戎感染老年患者灭活疫苗效力的报告较少。我们旨在展示轻症老年患者的临床特征，并初步评估疫苗的保护作用。本研究共纳入 13120 例 60 岁以上的轻症患者，收集并分析其病历。60 岁以上患者合并慢性基础疾病更多，ORF1ab 和 N 基因 CT 值显著更低，核酸转阴时间更长。与接种两剂疫苗的患者相比，接种加强针疫苗的老年患者 ORF1ab 和 N 基因 CT 值更高。未接种疫苗的老年患者核酸转阴时间最长，从接种两剂疫苗到接种加强针疫苗呈逐渐下降趋势。我们还使用随机森林和逻辑回归筛选与核酸转换时间密切相关的因素，并预测核酸转换时间。对于奥密克戎感染的轻症患者，与年轻患者相比，>60 岁的老年患者临床症状较轻，病毒载量更高，核酸转阴时间更长。灭活 SARS-CoV-2 疫苗为奥密克戎变异株感染的成年人提供了有效保护，三剂疫苗的有效性大于两剂疫苗。应特别关注老年患者。
